Patient-specific CT-based 3D passive FSI model for left ventricle in hypertrophic obstructive cardiomyopathy.
Patient-specific CT-based 3D passive FSI model for left ventricle in hypertrophic obstructive cardiomyopathy.
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基于 CT 的患者特异性肥厚性梗阻性心肌病左心室 3D 被动 FSI 模型
DOI：
10.1080/10255842.2018.1443215
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发表时间：
2018-03
影响因子：
1.6
通讯作者：
Tang D
中科院分区：
文献类型：
--
作者：
Deng L;Huang X;Yang C;Song Y;Tang D
摘要肥厚型心肌病患者中有70%发生左室流出道梗阻，一般人群中每500名成人中约有1名发生左室流出道梗阻。人们普遍认为，二尖瓣的运动，特别是其收缩期前向运动（SAM），显著地归因于这种阻塞。为了更好地了解二尖瓣运动，在这项研究中，提出了一个三维的患者特定的流体-结构相互作用模型的肥厚型梗阻性心肌病患者的基础上，计算机断层扫描（CT）扫描图像的左心室。提取左心室和二尖瓣内的位移、结构应力、压力、流速和剪应力来表征它们的行为。二尖瓣上的最大剪应力为9.68。二尖瓣后叶压力高于前叶，峰值压力为93.5 mm Hg，出现在SAM前。该患者的攻角较大（54.3 ± 22.4°）。本研究中建立的方法可能有可能澄清SAM的机制，并通过比较术前和术后模型获得的力学结果，最终优化手术计划。
Abstract Left ventricular outflow tract obstruction is observed in 70% of patients with hypertrophic cardiomyopathy, which occurs in about 1 of every 500 adults in the general population. It has been widely believed that the motion of the mitral valve, in particular, its systolic anterior motion (SAM), attributes significantly to such obstruction. For a better understanding of the mitral valve motion, a 3D patient-specific fluid-structure interaction model of the left ventricle from a patient with hypertrophic obstructive cardiomyopathy based on computed tomography (CT) scan images was proposed in this study. Displacement, structural stress, pressure, flow velocity and shear stress within the left ventricle and mitral valve were extracted to characterize their behavior. The maximum shear stress on mitral valve was 9.68 . The pressure on its posterior leaflet was higher than that on the anterior leaflet and the peak pressure on the mitral valve was 93.5 mm Hg which occurred at pre-SAM time. High angles of attack (54.3 ± 22.4°) were found in this patient. The methodology established in this study may have the potential to clarify the mechanisms of SAM and ultimately optimize surgical planning by comparing the mechanical results obtained from preoperative and postoperative models.
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影响因子：
4.7
作者：
Tang, Dalin;Yang, Chun;Geva, Tal;Gaudette, Glenn;del Nido, Pedro J.
通讯作者：
del Nido, Pedro J.
影响因子：
24
作者：
Kim, Luke K.;Swaminathan, Rajesh V.;Feldman, Dmitriy N.
通讯作者：
Feldman, Dmitriy N.
DOI：
10.1016/0735-1097(93)90196-8
发表时间：
1993-09-01
影响因子：
24
作者：
SHERRID, MV;CHU, CK;DWYER, EM
通讯作者：
DWYER, EM
DOI：
10.1115/1.2913339
发表时间：
2008-08
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Tang D;Yang C;Geva T;Del Nido PJ
通讯作者：
Del Nido PJ
DOI：
10.1016/s0735-1097(00)00830-5
发表时间：
2000-10-01
影响因子：
24
作者：
Sherrid, MV;Gunsburg, DZ;Pearle, G
通讯作者：
Pearle, G