Thyroid metastases from colorectal cancer: The Institut Gustave Roussy experience
Thyroid metastases from colorectal cancer: The Institut Gustave Roussy experience
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DOI：
10.1016/j.ejca.2005.11.042
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发表时间：
2006-08-01
影响因子：
8.4
通讯作者：
Malka, Dauid
中科院分区：
文献类型：
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作者：
Lievre, Astrid;Leboulleux, Sophie;Malka, Dauid
结直肠癌（CRC）患者甲状腺转移的患病率尚不清楚。我们检索了1993-2004年期间所有经病理证实的结直肠癌甲状腺转移患者的记录。在5862例连续CRC患者中，6例（0.1%）被诊断为甲状腺转移，原发肿瘤诊断后的中位时间为61个月，其他转移灶（所有病例均存在）的最后一次手术切除或射频消融后的中位时间为19个月。体征和症状（n = 3）包括颈部疼痛、颈部淋巴结病、甲状腺肿、吞咽困难和/或发音困难。在其他情况下，诊断是由正电子发射断层扫描。5例孤立性甲状腺转移瘤患者行甲状腺切除术，均行颈淋巴结清扫术。唯一一名因合并肝和肺转移而接受保守治疗的患者发生了危及生命的呼吸困难，需要紧急气管支架植入术。在诊断原发性CRC、初始转移和甲状腺转移后，中位总生存期分别为77个月、58个月和12个月。结论是甲状腺转移是罕见的，发生在CRC的后期。甲状腺切除术（伴颈淋巴结清扫术）可预防或改善危及生命的症状并延长生存期。(c)2006爱思唯尔有限公司保留所有权利。
The prevalence of thyroid metastases in colorectal cancer (CRC) patients is unknown. We retrieved the records of all patients with CRC and pathologically proved thyroid metastasis for the period 1993-2004. Among 5862 consecutive patients with CRC, 6 (0.1%) were diagnosed with thyroid metastases, a median of 61 months after the diagnosis of primary tumour, and a median of 19 months after the last surgical resection or radiofrequency ablation of other metastases (which were present in all cases). Signs and symptoms, when present (n = 3), consisted of cervical pain, cervical adenopathy, goitre, dysphagia, and/or dysphonia. In other cases, the diagnosis was made by positron emission tomography scanning. Thyroidectomy was performed in the 5 patients with isolated thyroid metastases, with cervical lymph node dissection being required in all cases. The only patient treated conservatively because of concomitant liver and lung metastases developed life-threatening dyspnoea, which required emergent tracheal stenting. Median overall survival was 77 months, 58 months, and 12 months after the diagnosis of primary CRC, initial metastases, and thyroid metastasis, respectively. It is concluded that thyroid metastases are rare and occur late in the course of CRC. Thyroidectomy (with cervical lymph node dissection) may result in prevention or improvement of life-threatening symptoms and prolonged survival. (c) 2006 Elsevier Ltd. All rights reserved.