Bio-relevant cobalt(II) complexes with compartmental polyquinoline ligand: Synthesis, crystal structures and biological activities
Bio-relevant cobalt(II) complexes with compartmental polyquinoline ligand: Synthesis, crystal structures and biological activities
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具有隔室聚喹啉配体的生物相关钴(II)配合物：合成、晶体结构和生物活性
DOI：
10.1016/j.jinorgbio.2014.11.003
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发表时间：
2015
影响因子：
3.9
通讯作者：
Yan Shi-Ping
中科院分区：
文献类型：
--
作者：
Li Jun-Ling;Jiang Lin;Wang Bi-Wei;Tian Jin-Lei;Gu Wen;Liu Xin;Yan Shi-Ping
合成了三个新的Co（II）配合物[Co4(L)2(μ3-CrO4)2](ClO4)2·2CH3CN (1), [Co2(L)(μ2-na)(H2O)](ClO4)2(2)和[Co2(L)(μ2-ba)](ClO4)2·0.5CH3CN （3) （Hna =烟酸，Hba =苯甲酸，HL=N，N,N ',N ' -四akis（2-喹啉甲基）-1,3-二氨基丙烯-2-醇）），并通过各种物理化学技术对其进行了表征。Co（II）中心由内源性烷氧基桥连接，并通过各种外部辅助连接，其中一些显示配位数不对称（5,6 -配位的1和2；5,5 -配位的3）。值得一提的是，配合物1含有两个罕见的μ3-η1，η1，η1- cro42−基团。三种配合物的磁化率数据表明，高自旋Co（II）原子在分子内反铁磁耦合，交换积分值(J)分别为- 14.94 cm−1、- 11.26 cm−1和- 13.66 cm−1。利用吸收光谱滴定法、溴化乙啶（EB）置换法和黏度法研究了化合物与小牛胸腺DNA （CT-DNA）的相互作用，结果表明化合物与CT-DNA的结合具有中等的插层模式，亲和顺序为：1>2≈3。三个复合物表现出pBR322质粒DNA的氧化裂解，包括依赖h2o2作为激活剂。化合物1与化合物2和化合物3相比，具有较强的DNA裂解活性，可在较低浓度（5 μM）下将超螺旋DNA （SC DNA）降解为缺口螺旋DNA （NC DNA）。此外，所有化合物都能在静态猝灭过程中猝灭牛血清白蛋白（BSA）的固有荧光。复合物1在24 h和48 h的ic50值均低于顺铂，其抗癌活性也高于顺铂。
Three new Co(II) complexes, [Co4(L)2(μ3-CrO4)2](ClO4)2· 2CH3CN (1), [Co2(L)(μ2-na)(H2O)](ClO4)2(2) and [Co2(L)(μ2-ba)](ClO4)2· 0.5CH3CN (3) (Hna = nicotinic acid, Hba = benzoic acid, HL=N,N,N′,N′-tetrakis (2-quinolylmethyl)-1,3-diaminopropan-2-ol), have been synthesized and characterized by various physicochemical techniques. The Co(II) centers are connected by endogenous alkoxy bridge fromL−and various extrinsic auxiliary linkers, some of which display coordination number asymmetry (5, 6-coordinated for1and2; 5, 5-coordinated for3). It is worth mentioning that complex1contains two rare reportedμ3-η1,η1,η1-CrO42−moieties. Susceptibility data of three complexes indicated intramolecular antiferromagnetic coupling of high-spin Co(II) atoms with exchange integral values (J) − 14.94 cm− 1, − 11.26 cm− 1and − 13.66 cm− 1for1,2and3, respectively. Interaction of compounds with calf thymus DNA (CT-DNA) have been investigated by absorption spectral titration, ethidium bromide (EB) displacement assay and viscosity measurement, which revealed that compounds bound to CT-DNA with a moderate intercalative mode, accompanied the affinities order:1>2≈3. Three complexes exhibit oxidative cleavage of pBR322 plasmid DNA including a reliance on H2O2as the activator. Compound1demonstrates an increased DNA cleavage activity as compared with2and3, which could degrade super coiled DNA (SC DNA) into nicked coiled DNA (NC DNA) in lower concentration (5 μM). Moreover, all compounds could quench the intrinsic fluorescence of bovine serum albumin (BSA) in a static quenching process. Complex1also shows higher anticancer activity than cisplatin with lower IC50value of incubation for both 24 h and 48 h.