Gut microbiome composition and diversity are related to human personality traits.
Gut microbiome composition and diversity are related to human personality traits.
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DOI：
10.1016/j.humic.2019.100069
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发表时间：
2020-03
影响因子：
--
通讯作者：
Johnson KV
中科院分区：
文献类型：
--
作者：
Johnson KV
研究肠道微生物组的组成和多样性与人类性格的关系。分析与动物和人类精神病学研究中的行为相关的目标细菌属。根据性格对细菌属进行建模（使用负二项式回归）。与自闭症相关的属也与一般人群的社会行为有关。社交能力与较高的多样性相关，而焦虑和压力则与较低的多样性相关。肠道微生物组对大脑有显着影响，影响压力、焦虑、抑郁症状和社会行为。这种微生物组-肠-脑轴可能由多种机制介导，包括神经、免疫和内分泌信号传导。迄今为止，大多数研究都是在动物模型中进行的，而有限的人体研究则集中在精神疾病上。这里根据人类性格研究肠道微生物组的组成和多样性。使用回归模型来控制可能的混杂因素，特定细菌属的丰度被证明可以通过人格特征显着预测。肠道微生物组的多样性分析表明，拥有较大社交网络的人往往拥有更多样化的微生物组，这表明社交互动可能会塑造人类肠道的微生物群落。相反，焦虑和压力与多样性减少和微生物组组成改变有关。总之，这些结果为我们对人格的理解增加了一个新的维度，并揭示微生物组-肠-脑轴也可能与普通人群的行为变异以及精神疾病病例有关。
Investigation of gut microbiome composition and diversity with respect to human personality. Analyses targeted bacterial genera linked to behaviour in animal and human psychiatric studies. Bacterial genera were modelled (using negative binomial regression) with respect to personality. Genera linked to autism are also related to social behaviour in the general population. Sociability is associated with higher diversity, and anxiety and stress with reduced diversity. The gut microbiome has a measurable impact on the brain, influencing stress, anxiety, depressive symptoms and social behaviour. This microbiome–gut–brain axis may be mediated by various mechanisms including neural, immune and endocrine signalling. To date, the majority of research has been conducted in animal models, while the limited number of human studies has focused on psychiatric conditions. Here the composition and diversity of the gut microbiome is investigated with respect to human personality. Using regression models to control for possible confounding factors, the abundances of specific bacterial genera are shown to be significantly predicted by personality traits. Diversity analyses of the gut microbiome reveal that people with larger social networks tend to have a more diverse microbiome, suggesting that social interactions may shape the microbial community of the human gut. In contrast, anxiety and stress are linked to reduced diversity and an altered microbiome composition. Together, these results add a new dimension to our understanding of personality and reveal that the microbiome–gut–brain axis may also be relevant to behavioural variation in the general population as well as to cases of psychiatric disorders.