Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis
Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis
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DOI：
10.1086/375819
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发表时间：
2003-08-01
影响因子：
11.8
通讯作者：
Hillier, SL
中科院分区：
文献类型：
--
作者：
Cherpes, TL;Meyn, LA;Hillier, SL
对18-30岁的性活跃妇女进行了一项纵向队列研究，以确定与获得2型单纯疱疹病毒(HSV-2)感染相关的变量。670名HSV-2血清阴性的妇女每隔4个月进行一年的跟踪调查，其中32名妇女检测到HSV-2抗体的获得。单因素分析显示，黑人、受教育年限小于或等于12年、有新的性伴、细菌性阴道病(BV)与HSV-2血清转换相关。先前的HSV-1感染对HSV-2感染没有保护作用。在多变量模型中控制了其他已确定的风险因素后，BV的诊断仍然与感染HSV-2的风险增加有关(风险比，2.1；95%可信区间，1.0-4.5；P=0.05)。在这项研究中，BV对HSV-2血清转换的人群归因风险为21%。还需要进一步的研究来确定BV的筛查和治疗是否可以降低女性感染HSV-2的易感性。
A longitudinal cohort study of sexually active women 18 - 30 years of age was conducted to identify variables associated with the acquisition of herpes simplex virus type 2 (HSV-2) infections. Six hundred seventy HSV-2 - seronegative women were followed up at 4-month intervals for 1 year; acquisition of HSV-2 antibodies was detected in 32 of these women. Black race, less than or equal to12 years of education, having a new sex partner, and bacterial vaginosis (BV) were associated with HSV-2 seroconversion on univariate analysis. Antecedent HSV-1 infection was not protective against HSV-2 acquisition. After controlling for other identified risk factors in multivariable models, the diagnosis of BV remained associated with an increased risk of acquiring HSV-2 infection ( hazard ratio, 2.1; 95% confidence interval, 1.0 - 4.5; P = .05). In this study, the population attributable risk of BV for HSV-2 seroconversion was 21%. Additional studies are needed to determine whether screening and treatment of BV could reduce susceptibility to the acquisition of HSV-2 in women.