tDCS-induced modulation of GABA concentration and dopamine release in the human brain: A combination study of magnetic resonance spectroscopy and positron emission tomography
tDCS-induced modulation of GABA concentration and dopamine release in the human brain: A combination study of magnetic resonance spectroscopy and positron emission tomography
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DOI：
10.1016/j.brs.2020.12.010
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发表时间：
2021-01-01
影响因子：
7.7
通讯作者：
Ouchi, Yasuomi
中科院分区：
文献类型：
--
作者：
Bunai, Tomoyasu;Hirosawa, Tetsu;Ouchi, Yasuomi
背景：经颅直流电刺激前额叶背外侧皮质(DLPFC)可能通过促进或抑制主要在大脑皮层的神经元活动来调节认知功能。目的：研究γ-氨基丁酸(GABA)浓度与tDCS后多巴胺释放之间的相互作用。方法：本研究采用随机、安慰剂对照、双盲、交叉设计。17名健康男性受试者分别接受了正电子发射断层扫描(TDC)检查(每隔20分钟，每次13分钟)，阳极位于左侧，阴极位于右侧，然后进行[C-11]拉克洛必利正电子发射断层扫描(PET)和GABA磁共振波谱(MRS)检查。MRS体素定位于左侧DLPFC和双侧纹状体。对PET和MRS参数进行配对t检验和回归分析。结果：MRS数据分析显示，激活tDCs后，左侧纹状体GABA水平升高，右侧纹状体和左侧DLPFC中度下降。PET数据分析显示，激活tDCs后，右侧纹状体[C-11]-raclopide结合电位的降低(多巴胺释放增加)与左侧纹状体的[C-11]-raclopide结合电位降低呈负相关。左侧DLPFC的GABA减少与左侧纹状体内GABA的升高、右侧纹状体多巴胺释放的增加呈正相关，与左侧纹状体多巴胺释放的增加呈负相关。结论：DLPFC的tDCs对基底节皮层环路中的多巴胺-GABA功能有调节作用。(C)2020年提交人(S)。由爱思唯尔公司出版。
Background: Transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (DLPFC) hypothetically modulates cognitive functions by facilitating or inhibiting neuronal activities chiefly in the cerebral cortex. The effect of tDCS in the deeper brain region, the basal ganglia-cortical circuit, remains unknown.Objective: To investigate the interaction between gamma-aminobutyric acid (GABA) concentrations and dopamine release following tDCS.Method: This study used a randomized, placebo-controlled, double-blind, crossover design. Seventeen healthy male subjects underwent active and sham tDCS (13 min twice at an interval of 20 min) with the anode placed at the left DLPFC and the cathode at the right DLPFC, followed by examinations with [C-11]raclopride positron emission topography (PET) and GABA-magnetic resonance spectroscopy (MRS). MRS voxels were set in the left DLPFC and bilateral striata. Paired t-tests and regression analyses were performed for PET and MRS parameters.Results: MRS data analyses showed elevations in GABA in the left striatum along with moderate reductions in the right striatum and the left DLPFC after active tDCS. PET data analyses showed that reductions in [C-11]-raclopride binding potentials (increase in dopamine release) in the right striatum were inversely correlated with those in the left striatum after active tDCS. GABA reductions in the left DLPFC positively correlated with elevations in GABA in the left striatum and with increases in right striatal dopamine release and negatively correlated with increases in left striatal dopamine release.Conclusion: The present results suggest that tDCS to the DLPFC modulates dopamine-GABA functions in the basal ganglia-cortical circuit. (c) 2020 The Author(s). Published by Elsevier Inc.