Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation
Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation
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DOI：
10.1007/s10014-012-0118-9
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发表时间：
2013-07-01
影响因子：
3.3
通讯作者：
Hamada, Jun-ichiro
中科院分区：
文献类型：
--
作者：
Yoshikawa, Akifumi;Nakada, Mitsutoshi;Hamada, Jun-ichiro
一名 63 岁女性出现头晕、步态障碍和食欲不振的症状。 MRI显示病灶位于延髓，T2加权呈高信号，有轻微强化，钆T1加权出现在肿块腹侧。诊断为高级别脑干胶质瘤，患者接受了放化疗。然而，她在治疗18天后死亡，并进行了尸检。病理诊断为胶质母细胞瘤（GBM），具有未甲基化的O-6-甲基鸟嘌呤-DNA甲基转移酶启动子和野生异柠檬酸脱氢酶1基因。我们通过遗传分析报告了延髓成人 GBM 的极短临床病程，并对文献进行了回顾。
A 63-year-old woman presented with dizziness followed by gait disturbance and loss of appetite. Magnetic resonance image (MRI) showed that a lesion located in the medulla oblongata, appearing as hyperintense on T2-weighted image and with slight enhancement area, appeared in the ventral aspect of the mass on T1-weighted MR imaging with gadolinium. It was diagnosed as high-grade brain-stem glioma and the patient underwent chemoradiotherapy. However, she died 18 days after treatment, and autopsy was performed. The pathological diagnosis was glioblastoma (GBM) with unmethylated O-6-methylguanine-DNA methyltransferase promoter and wild isocitrate dehydrogenase 1 gene. We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature.