Control of early viral and bacterial distribution and disease by natural antibodies
Control of early viral and bacterial distribution and disease by natural antibodies
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DOI：
10.1126/science.286.5447.2156
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发表时间：
1999-12-10
期刊：
影响因子：
56.9
通讯作者：
Zinkernagel, RM
中科院分区：
文献类型：
--
作者：
Ochsenbein, AF;Fehr, T;Zinkernagel, RM
天然抗体通常作为“背景”从免疫学分析中排除，但它们在赋予抗感染的免疫力方面可能发挥重要作用。在感染各种病毒或单核细胞增生李斯特菌的无抗体小鼠中，外周器官（包括肾脏和大脑）中的病毒或细菌滴度比抗体感受态小鼠高10至100倍（并增强了它们对某些感染的易感性），而次级类扁桃体器官中的滴度比抗体感受态小鼠低10至100倍。因此，天然抗体通过防止病原体传播到重要器官和通过增强次级类寄生虫器官中的抗原捕获来提高免疫原性而发挥关键作用。
Natural antibodies are often dismissed from immunological analysis as "background," but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary Lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary Lymphoid organs.