Sedentary time, physical activity, and serum SPARC in a middle-aged population
Sedentary time, physical activity, and serum SPARC in a middle-aged population
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中年人群的久坐时间、体力活动和血清 SPARC
DOI：
10.1080/17461391.2021.1974573
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发表时间：
2021
影响因子：
3.2
通讯作者：
Tanaka K
中科院分区：
文献类型：
--
作者：
Nishida Y;Hara M;Higaki Y;Taguchi N;Nakamura K;Nanri H;Imaizumi T;Sakamoto T;Shimanoe C;Horita M;Shinchi K;Tanaka K
习惯性体力活动(PA)对富含半胱氨酸的酸性分泌蛋白(SPARC)循环水平的影响尚不清楚。本研究的目的是阐明安静时间、光强度PA(LPA)和中强度PA(MVPA)对一般中年人群血清SPARC的影响。目前的研究是一项针对4000名男性和6040名女性(40-69岁)的横断面研究。用加速度计客观测量坐位时间、LPA和MVPA。采用酶联免疫吸附试验检测血清SPARC浓度。使用等时替代模型，根据性别分析了用LPA或MVPA取代久坐时间对血清SPARC水平的横截面关联。与受试者特征的相互作用，如身体质量指数(BMI)、吸烟和饮酒，也被检查出来。在男性中，在调整包括体重指数在内的混杂因素后，用60 分钟的MVPA取代60 分钟的静坐时间与降低23 ng/mL的血清SPARC值(可信区间：−43，−2)显著相关(P= 0.028)。在女性中检测到用低密度脂蛋白取代久坐行为与SPARC上的体重指数之间的显著交互作用(P= 0.029)，尽管每种体重指数水平(25或≥25 kg/m2)的分层关联没有达到显著意义。目前的研究表明，在中年男性中，用MVPA取代久坐时间与血清SPARC水平的降低有关，但在女性中没有。此外，在女性中也发现了LPA和BMI对SPARC的潜在交互作用。亮点一项等时替代分析表明，用中等强度到剧烈的体力活动(MVPA)取代久坐行为与男性血清SPARC水平的降低有关。在女性中，没有观察到用MVPA取代久坐行为与SPARC水平之间的负关联。在女性中也发现了用轻强度PA取代久坐行为与身体质量指数对血清SPARC水平的潜在交互作用。
The influence of habitual physical activity (PA) on the circulating levels of secreted protein acidic and rich in cysteine (SPARC) remains unclear. The purpose of the current study was to clarify the effects of sedentary time, light-intensity PA (LPA), and moderate- to vigorous-intensity PA (MVPA) on the serum SPARC in a general middle-aged population. The current study is a cross-sectional study of 4,000 men and 6,040 women (40–69 years). Sedentary time, LPA, and MVPA were objectively measured by an accelerometer. The serum SPARC concentration was measured by enzyme-linked immunosorbent assay. Using an isotemporal substitution model, cross-sectional associations of replacing sedentary time with either LPA or MVPA on serum SPARC levels were analysed according to sex. Interactions with subject characteristics, such as the body mass index (BMI), smoking, and alcohol consumption, were also examined. In men, replacing 60 min of sedentary time with 60 min of MVPA was significantly associated with 23 ng/mL lower serum SPARC levels (confidence interval: −43, −2) after adjusting for confounders, including the BMI (P= 0.028). A significant interaction between replacing sedentary behaviour with LPA and the BMI on SPARC was detected in women (P= 0.029), although the stratified associations for each BMI level (<25 or ≥25 kg/m2) did not reach significance. The current study suggests that replacing sedentary time with MVPA is associated with reduced serum SPARC levels in middle-aged men, but not in women. In addition, a potential interaction between LPA and the BMI on SPARC was also found in women.HighlightsAn isotemporal substitution analysis showed that replacing sedentary behaviour with moderate- to vigorous-intensity physical activity (MVPA) is associated with decreased serum SPARC levels in men.Such an inverse association between replacing sedentary behaviour with MVPA and the SPARC levels was not observed in women.A potential interaction between replacing sedentary behaviour with light-intensity PA and the body mass index on the serum SPARC levels was also found in women.