New drugs, new vaccines, new diseases. An interview with Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID).
New drugs, new vaccines, new diseases. An interview with Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID).
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新药物、新疫苗、新疾病。
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发表时间：
1996
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影响因子：
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通讯作者：
J. Fuller
中科院分区：
文献类型：
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作者：
J. Fuller
本文介绍了对安东尼·福奇博士的采访，内容是关于新一代疫苗的开发，以预防并可能根除从结核病到艾滋病等一系列致命疾病。在当今世界上造成重大疾病的感染包括结核病、疟疾、血吸虫病、丝虫病、肺炎球菌肺炎、流感、艾滋病和埃博拉病毒。各机构应确保微生物学、免疫学、抗菌素和疫苗学的基础研究处于最高水平。国家间研究工作的一体化取决于母国调查人员与外国调查人员之间的合作。疫苗学的新发展包括用于百日咳/百日咳（一种导致死亡的极度传染性疾病）的无细胞百日咳疫苗，DNA免疫（一种适用于所有类型疾病的新技术），以及用于免疫肝炎，百日咳和脊髓灰质炎的转基因植物。截至目前，西方国家的艾滋病发病率有所下降，而非洲和亚洲的艾滋病发病率有所加快。艾滋病的联合治疗对体内病毒的水平产生了深远的影响;然而，治疗方法仍然模糊。关于艾滋病的好消息是，教育正在产生影响;泰国的情况就是一个例子，该国政府与非政府组织和军方一道，开始了一场关于妓女和使用避孕套的速成教育运动。在寻找更好的候选疫苗方面正在取得进展。然而，从长期的历史趋势来看，在未来的某个时候，类似艾滋病的流行病必然会出现新的疾病。
This document presents an interview with Dr. Anthony Fauci on the development of a new generation of vaccines to prevent and possibly eradicate a legion of deadly diseases ranging from tuberculosis to AIDS. Infections that have caused major devastations in the world today include tuberculosis, malaria, schistosomiasis, filariasis, pneumococcal pneumonia, influenza, AIDS, and Ebola. Agencies should be making sure that the basic research base in microbiology, immunology, antimicrobials, and vaccinology is at the very highest level. The integration of research efforts between countries depends on collaboration between the investigators of home countries with foreign investigators. Among new developments in vaccinology are an acellular pertussis vaccine for pertussis/whooping cough (an extremely contagious disease that causes death), DNA immunization (a new technique applicable to all types of diseases), and transgenic plants for immunization against hepatitis, pertussis, and polio. As of now, AIDS in Western countries has declined, while in Africa and Asia its spread has accelerated. Combination therapy for AIDS has had a profound impact on the level of the virus in the body; however, the treatment is still vague. The good news with regard to AIDS is that education is having an impact; this is exemplified by the situation in Thailand, where the government together with nongovernmental organizations and the military has begun a crash education campaign regarding prostitutes and the use of condoms. Progress is being made in the search for better vaccine candidates. AIDS-like epidemics involving new diseases are bound to emerge at some future point, though, given the long-term historical trend.