Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials
Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials
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DOI：
10.1021/acs.langmuir.6b02406
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发表时间：
2016-11-29
期刊：
影响因子：
3.9
通讯作者：
Akiyoshi, Kazunari
中科院分区：
文献类型：
--
作者：
Tahara, Yoshiro;Sakiyama, Mizuki;Akiyoshi, Kazunari
羟丙基纤维素（HPC）是一种极具吸引力的多糖，可用于开发纳米凝胶作为纳米凝胶构造材料的热响应性构建单元。含胆固醇的HPC （Ch-HPC）通过胆固醇基在水中的疏水相互作用自组装形成纳米凝胶。Ch-HPC纳米凝胶的临界溶解温度低于天然HPC。Ch-HPC纳米凝胶的粒径受温度和盐析效应的可逆控制。在Ch-HPC纳米凝胶-交联大凝胶中也观察到热响应特性。这些结果表明，Ch-HPC纳米凝胶是一种具有吸引力的热响应纳米凝胶构造材料。
Hydroxypropyl cellulose (HPC) is a fascinating polysaccharide to use in developing a nanogel to be a thermoresponsive building unit for nanogel tectonic materials. Cholesterol-bearing HPC (Ch-HPC) self-assembled to form nanogels through hydrophobic interactions of the cholesteryl groups in water. Ch-HPC nanogels had a lower critical solution temperature in line with that of native HPC. The particle size of Ch-HPC nanogels was reversibly controlled by the temperature and salting-out effect. The thermoresponsive property was also observed in Ch-HPC nanogel-cross-linked macrogels. These results suggest that a Ch-HPC nanogel is an attractive building block for thermoresponsive nanogel tectonic materials.