The brainweb of cross-scale interactions
The brainweb of cross-scale interactions
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DOI：
10.1016/j.newideapsych.2010.11.001
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发表时间：
2011-08-01
影响因子：
2.6
通讯作者：
Le Van Quyen, Michel
中科院分区：
文献类型：
--
作者：
Le Van Quyen, Michel
从神经元到行为，神经系统在许多层次的组织上运作，每个层次都有自己的时间和空间尺度。随着新的生理记录技术和功能神经成像技术的爆炸性增长，现在可以从这些多个水平获得非常大的数据集。最困难的任务之一是构思和描述不同层次之间的交换，因为时间和距离的尺度编织在一个复杂的相互作用网络中，而且层次之间的因果推理比层次内的模糊得多。在这篇论文中。我认为，对这些多水平相互作用的一般描述可以基于在多个频率和不同空间尺度上工作的神经元振荡的时间协调。具体地说，在每个特征频率上的振荡的幅度受到由较低频率的振荡引起的神经元兴奋性的周期性变化的调制，并且在更大的空间尺度上同时出现。遵循这一普遍规律，全球一体化模式可能产生下行影响，偶尔会作用于并限制局部水平的细胞组件，因此其活动可被视为下行影响的标志。这种跨尺度的框架牢固地植根于神经生理学，因此完全可以接受实验测试。(C)2010年由爱思唯尔有限公司出版。
From neuron to behaviour, the nervous system operates on many levels of organization, each with its own scales of time and space. Very large sets of data can now be obtained from these multiple levels by the explosive growth of new physiological recording techniques and functional neuroimaging. Among the most difficult tasks are those of conceiving and describing the exchanges between levels, seeing that the scales of time and distance are braided together in a complex web of interactions, and that causal inference is far more ambiguous between than within levels. In this paper. I propose that a generic description of these multi-level interactions can be based on the temporal coordination of neuronal oscillations that operate at multiple frequencies and on different spatial scales. Specifically, the amplitude of the oscillations at each characteristic frequency is modulated by cyclical variations in neuronal excitability induced by lower frequency oscillations and emerging simultaneously on a larger spatial scale. Following this general rule, global patterns of integration can produce downward effects, occasionally acting on and constraining the local level of cell assemblies, whose activity can thus be taken as a signature of the downward influence. This cross-scale framework is firmly rooted in neurophysiology and as such is entirely amenable to experimental testing. (C) 2010 Published by Elsevier Ltd.