Immunohistopathological study of the oral lichenoid lesions of chronic GVHD
Immunohistopathological study of the oral lichenoid lesions of chronic GVHD
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DOI：
10.1111/j.1600-0714.2005.00372.x
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Ueyama, Y
中科院分区：
文献类型：
--
作者：
Sato, M;Tokuda, N;Ueyama, Y
背景：慢性移植物抗宿主病（cGVHD）是骨髓移植（BMT）后常见且严重的并发症。然而，cGVHD口腔苔藓样病变的详细过程仍不清楚。因此，我们与口腔扁平苔藓 (OLP) 和健康对照相比，研究了 cGVHD 的免疫组织病理学特征。方法：对 19 名组织病理学诊断为 cGVHD 的同种异体 BMT 受者进行了调查。我们比较了cGVHD与OLP和健康对照的免疫组织病理学特征。结果：免疫组织病理学特征显示，cGVHD和OLP的CD4阳性T细胞浸润明显大于正常口腔黏膜（P < 0.005）。与正常口腔黏膜相比，cGVHD和OLP中CD8阳性T细胞浸润数量较多（P < 0.001）。 cGVHD 和 OLP 之间 CD4 和 CD8 阳性 T 细胞数量差异不显着。 cGVHD和OLP中朗格汉斯细胞（CD1a）的浸润明显大于正常口腔粘膜（P < 0.005）。 cGVHD和OLP之间的朗格汉斯细胞数量差异不显着。 CD68阳性巨噬细胞在cGVHD和OLP中比在正常口腔粘膜中更常见（P < 0.0001）。 cGVHD和OLP之间CD68阳性巨噬细胞数量差异不显着。结论：朗格汉斯细胞和CD8阳性T细胞可能在cGVHD口腔苔藓样病变的发病机制中起主要作用，本研究在OLP和cGVHD口腔苔藓样病变中诱导免疫反应。
BACKGROUND: Chronic graft-vs.-host disease (cGVHD) is a common and serious complication after bone marrow transplantation (BMT). However, the detailed process of oral lichenoid lesions of cGVHD is still unknown. Therefore, we investigated the immunohistopathological features of cGVHD compared with oral lichen planus (OLP) and healthy controls.METHODS: Nineteen allogenic BMT recipients with a histopathological diagnosis of cGVHD were investigated. We investigated the immunohistopathological features of cGVHD compared with OLP and healthy controls.RESULTS: Immunohistopathological features showed that the infiltrations of CD4-positive T cells of cGVHD and OLP were significantly larger than those of the normal oral mucosa (P < 0.005). A larger number of CD8-positive T cells was infiltrated in cGVHD and OLP compared with the normal oral mucosa (P < 0.001). The difference in the number of CD4- and CD8-positive T cells between cGVHD and OLP was not significant. The infiltrations of Langerhans cells (CD1a) in cGVHD and OLP were significantly larger than those in the normal oral mucosa (P < 0.005). The difference in the number of Langerhans cells between cGVHD and OLP was not significant. CD68-positive macrophages were more frequently seen in cGVHD and OLP than in the normal oral mucosa (P < 0.0001). The difference in the number of CD68-positive macrophages between cGVHD and OLP was not significant.CONCLUSIONS: It is suggested that Langerhans cells and CD8-positive T cell may play a major role in the pathogenesis of the oral lichenoid lesions of cGVHD, and the immune response was inducted in OLP as well as the oral lichenoid lesion of cGVHD in this study.