Biotin deficiency in an adult during home parenteral nutrition.
Biotin deficiency in an adult during home parenteral nutrition.
复制标题
成人家庭肠外营养期间生物素缺乏。
DOI：
10.1001/jama.1982.03320470062035
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
G. Onstad
中科院分区：
文献类型：
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作者：
C. McClain;H. Baker;G. Onstad
人类生物素缺乏症极为罕见，可能是因为这种维生素在饮食中无处不在，也是由肠道植物群产生的。生鸡蛋白色含有一种蛋白质，抗生物素蛋白，它紧密结合生物素，使其难以吸收。1942年，Sydenstricker等人通过给成年志愿者喂食添加了200 g脱水白色鸡蛋的饮食，诱导他们缺乏生物素。产生生物素缺乏的症状，每天注射75至300 μg生物素可逆转。最近的报道描述了婴儿在生物素依赖酶的代谢方面存在先天性缺陷，以及生物素缺乏症的体征和症状。2，3描述了一例患有短肠综合征的儿童，其生物素缺乏的体征与肠外营养和抗生素治疗相关，这些体征在每天给予10 mg生物素后逆转。4、调查人员认为，
BIOTIN deficiency in man has been extremely rare, presumably because this vitamin is ubiquitous in the diet and is also produced by the gut flora. Raw egg white contains a protein, avidin, which tightly binds biotin and renders it poorly absorbed. In 1942 Sydenstricker et al 1 induced biotin deficiency in adult volunteers by feeding them a diet to which 200 g of dehydrated egg white had been added. Symptoms of biotin deficiency were produced that reversed with daily injections of 75 to 300 μg of biotin. More recent reports have described infants with inborn errors in the metabolism of biotin-dependent enzymes and signs and symptoms of biotin deficiency. 2,3 One child with short-bowel syndrome has been described in which signs of biotin deficiency appeared in association with parenteral nutrition and antibiotic therapy, and these signs reversed with administration of 10 mg of biotin a day. 4 These investigators presumed this