Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers
Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers
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DOI：
10.1021/nl801828z
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发表时间：
2009-01-01
期刊：
影响因子：
10.8
通讯作者：
Simeonova, Petia P.
中科院分区：
文献类型：
--
作者：
Erdely, Aaron;Hulderman, Tracy;Simeonova, Petia P.
纳米技术是一个新兴的领域，迫切需要适当的毒理学和风险评估的发展。先前关于碳纳米管呼吸暴露的实验数据强烈表明需要对潜在毒性进行复杂的评价。我们的工作表明，碳纳米管沉积在肺部后，急性局部和全身反应被激活，其特征在于血液基因和蛋白质表达特征。这里描述的方法将促进生物标志物的发展，用于人类筛选纳米颗粒暴露。
Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure.