Correlations of microRNA: microRNA expression patterns reveal insights into microRNA clusters and global microRNA expression patterns
Correlations of microRNA: microRNA expression patterns reveal insights into microRNA clusters and global microRNA expression patterns
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DOI：
10.1039/c5mb00415b
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发表时间：
2016-01-01
影响因子：
--
通讯作者：
Fahlman, R. P.
中科院分区：
文献类型：
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作者：
Chaulk, S. G.;Ebhardt, H. A.;Fahlman, R. P.
MicroiRNA是基因组编码的小的双链RNA，其调节同源mRNA的表达。大约有2500种人类miRNA，每种都有数百种潜在的mRNA靶点，基于miRNA的基因调控在发育和疾病中都非常普遍。虽然有许多研究调查miRNA：mRNA和miRNA：蛋白质靶向表达相关性，但miRNA：miRNA共表达的研究相对较少。在这里，我们报告了我们的分析miRNA：miRNA共表达使用的表达数据从miRNA表达图谱的Landlord等人。我们的分析表明，许多，但不是所有的，基因组聚集的miRNA共表达作为一个单一的pri-miRNA转录。我们还鉴定了具有相似生物活性的共表达组。此外，我们发现的非相关miRNA已被证明在建立某些肿瘤和癌症的miRNA生物标志物和特征中具有实用性。
MicroiRNAs are genome encoded small double stranded RNAs that regulate expression of homologous mRNAs. With approximately 2500 human miRNAs and each having hundreds of potential mRNA targets, miRNA based gene regulation is quite pervasive in both development and disease. While there are numerous studies investigating miRNA: mRNA and miRNA: protein target expression correlations, there are relatively few studies of miRNA: miRNA co-expression. Here we report on our analysis of miRNA: miRNA co-expression using expression data from the miRNA expression atlas of Landgraf et al. Our analysis indicates that many, but not all, genomically clustered miRNAs are co-expressed as a single pri-miRNA transcript. We have also identified co-expression groups that have similar biological activity. Further, the non-correlative miRNAs we have uncovered have been shown to be of utility in establishing miRNA biomarkers and signatures for certain tumours and cancers.