Influence of husbandry and control measures on porcine circovirus type 2 (PCV-2) dynamics within a farrow-to-finish pig farm: A modelling approach
Influence of husbandry and control measures on porcine circovirus type 2 (PCV-2) dynamics within a farrow-to-finish pig farm: A modelling approach
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DOI：
10.1016/j.prevetmed.2009.07.009
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发表时间：
2009-11-01
影响因子：
2.6
通讯作者：
Madec, F.
中科院分区：
文献类型：
--
作者：
Andraud, M.;Rose, N.;Madec, F.
我们评估，使用建模方法，几个管理措施的影响，在一个仔猪到完成的农场PCV-2感染的年龄。还测试了不同接种方案的PCV-2疫苗接种对感染动力学的影响。建立了一个基于个体的随机模型，描述了一个典型的法国仔猪到肥育猪场的种群动态，并与PCV-2感染的流行病学模型相结合。传染模型的参数主要是从以前的传播实验中获得的。对结果进行感染时间的生存分析。对于每次比较，参考情况是未接种疫苗，随后在出生后和断奶后随机混合仔猪。当在不同阶段减少仔猪混合时，早期感染的风险显著降低（避免断奶后在小围栏中交叉饲养和按窝分组仔猪，风险比（HR）= 0.52 [0.46; 0.59]）。母猪靶向疫苗接种延迟了感染过程，直至被动免疫力减弱，仔猪靶向疫苗接种显著降低了感染力，导致感染总数急剧下降（HR = 0.44 [0.37; 0.54]）。当采取严格的管理措施时，效果甚至更明显（HR = 0.24 [0.19; 0.31]）。从PCV-2感染精液的低流行率（3%）到较高流行率（18%）的变化显著增加了早期感染的风险（HR = 1.36 [1.2; 1.53]），而降低替代率或将母猪舍从单独的板条箱改为群舍对PCV-2动态的影响有限。(C)2009爱思唯尔有限公司版权所有。
We assessed, using a modelling approach, the influence of several management practices within a farrow-to-finish farm on the age of PCV-2 infection. The impact of PCV-2 vaccination with different vaccination schemes on infection dynamics, was also tested. A stochastic individual-based model describing the population dynamics in a typical French farrow-to-finish pig farm was built and coupled with an epidemiological model of PCV-2 infection. The parameters of the infectious model were mainly obtained from previous transmission experiments. Results were subjected to a survival analysis of time-to-infection. For each comparison, the reference situation was no vaccination followed by random mixing of piglets after birth and after weaning. The risk of early infection was significantly reduced when mixing of piglets was reduced at different stages (avoiding cross-fostering and grouping piglets by litters in small pens after weaning, hazard ratio (HR) = 0.52 [0.46; 0.59]). Sow-targeted vaccination delayed the infectious process until the waning of passive immunity and piglet-targeted vaccination considerably decreased the force of infection leading to a dramatic decrease of the total number of infections (HR = 0.44 [0.37; 0.54]). The effect was even more pronounced when strict management measures were applied (HR = 0.24 [0.19; 0.31]). Changing from a low (3%) prevalence of PCV-2-infected semen to a higher one (18%) significantly increased the risk of early infections (HR = 1.36 [1.2; 1.53]), whereas reducing replacement rate or changing sow housing from individual crates to group housing had a limited impact on PCV-2 dynamics. (C) 2009 Elsevier B.V. All rights reserved.