Leukocyte telomere length correlates with glucose control in adults with recently diagnosed type 2 diabetes
Leukocyte telomere length correlates with glucose control in adults with recently diagnosed type 2 diabetes
复制标题
DOI：
10.1016/j.diabres.2017.10.020
复制
发表时间：
2018-01-01
影响因子：
5.1
通讯作者：
Amato, Angelica Amorim
中科院分区：
文献类型：
--
作者：
Campos Caldas Rosa, Erica Carine;Cruz dos Santos, Renan Renato;Amato, Angelica Amorim
目的：研究确诊时间不超过5年的2型糖尿病患者外周血白细胞相对端粒长度(TL)及其与临床和生化指标的关系。方法：采用定量聚合酶链式反应方法检测108例T2D患者(女性87例，男性21例)和年龄匹配的糖耐量正常对照组125例(女性37例，男性88例)外周血白细胞相对端粒长度。用多元线性回归分析T2D患者的相对TL与代谢控制的人口学、人体测量学和生化指标之间的关系。结果：T2D患者确诊后的中位时间为1年，大多数患者接受二甲双胍治疗，糖化血红蛋白水平决定了患者对血糖控制的满意程度。T2D患者和对照组之间的中位数相对TL没有差异。然而，多元线性回归分析显示，相对TL与T2D确诊后的时间、空腹血糖水平和HbA1c水平呈负相关，但与在调整年龄、性别和体重指数后5-12个月评估的HbA1c水平无关。结论：本研究表明，在新近诊断的T2D患者中，相对TL不短，但与血糖水平呈负相关，即使在总体血糖控制良好的患者中也是如此。(C)2017爱思唯尔B.V.保留所有权利。
Aims: We investigated leukocyte relative telomere length (TL) in patients with type 2 diabetes (T2D) diagnosed for no longer than five years and its association with clinical and biochemical variables.Methods: Peripheral blood leukocyte relative TL was investigated in 108 patients with T2D (87 women, 21 men) and 125 (37 women, 88 men) age-matched control subjects with normal glucose tolerance, by quantitative polymerase chain reaction. Multiple linear regression analysis was used to examine the association between relative TL and demographic, anthropometric and biochemical indicators of metabolic control among patients with T2D.Results: Patients with T2D had a median time since diagnosis of 1 year and most were on metformin monotherapy, with satisfactory glucose control determined by HbA1c levels. Median relative TL was not different between patients with T2D and control subjects. However, multiple linear regression analyses showed that relative TL was inversely associated with time since T2D diagnosis, fasting plasma glucose levels and HbA1c levels, but not with HbA1c levels assessed in the preceding 5-12 months, after adjustment for age, sex and body mass index.Conclusion: This study suggests that relative TL is not shorter in patients with recently diagnosed T2D, but is inversely correlated with glucose levels, even among patients with overall satisfactory glucose control. (C) 2017 Elsevier B.V. All rights reserved.