Two new nortriterpenoid saponins from Salicornia bigelovii Torr. and their cytotoxic activity
Two new nortriterpenoid saponins from Salicornia bigelovii Torr. and their cytotoxic activity
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DOI：
10.1016/j.fitote.2012.02.013
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发表时间：
2012-06-01
期刊：
影响因子：
3.4
通讯作者：
Feng, Xu
中科院分区：
文献类型：
--
作者：
Wang, Qi-zhi;Liu, Xiao-feng;Feng, Xu
海蓬子特征成分的研究。导致分离出两种新的 30-降三萜糖苷 Bigelovii A (1)、Bigelovii B (2)，以及两种已知的 30-降三萜糖苷 3-4 和三种已知的齐墩果烷型三萜糖苷 5-7。通过广泛的一维和二维核磁共振、质谱分析和化学证据阐明了新化合物的结构。所有化合物均为首次从藜科植物中分离得到。因此，评估了化合物1-4的细胞毒性，化合物1，3对四种细胞系HL-60(早幼粒细胞白血病)、MCF-7(乳腺癌)、HepG2(肝癌)和A549(肺癌)显示出中等活性，1的IC50值为6.18.78.08、13.64和>100μM； 31.87，>100，与100相似，>100μM分别为3。 (C) 2012 Elsevier B.V. 保留所有权利。
Investigation of characteristic constituents of Salicornia bigelovii Torr. led to isolation of two new 30-nortriterpenoid glycosides, Bigelovii A (1), Bigelovii B (2), together with two known 30-nortriterpenoid glycosides 3-4 and three known oleanane-type triterpenoid glycosides 5-7. The structures of new compounds were elucidated by extensive 1D and 2D NMR, and MS spectroscopic analysis, and chemical evidences. All compounds were isolated for the first time from Chenopodiaceae. Thus compounds 1-4 were evaluated for their cytotoxicity and compouds 1,3 showed moderate activity against four cell lines, HL-60 (promyelocytic leukemia), MCF-7 (breast carcinoma), HepG2 (liver carcinoma) and A549 (lung carcinoma), with IC50 values of 6.18.78.08, 13.64 and >100 mu M for 1; 31.87, >100, similar to 100, >100 mu M for 3, respectively. (C) 2012 Elsevier B.V. All rights reserved.