Avian and pandemic influenza: An overview
Avian and pandemic influenza: An overview
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DOI：
10.1016/j.vaccine.2007.01.050
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发表时间：
2007-04-20
期刊：
影响因子：
5.5
通讯作者：
Targonski, Paul V.
中科院分区：
文献类型：
--
作者：
Poland, Gregory A.;Jacobson, Robert M.;Targonski, Paul V.
甲型流感/H5 N1（禽流感）目前已造成258人感染（截至2006年11月13日），死亡率约为50%。由于该病毒在抗原类型方面是新的，并会引起感染和疾病，而且由于人类没有预先存在的免疫力，因此存在可能发生大流行的条件。此外，野生候鸟似乎正在更大的地理区域传播病毒，新的进化枝2型A/H5 N1流感病毒已经开始出现。美国国会预算办公室已经正式模拟了大流行性流感的可能后果，并估计多达200万美国人口可能死亡，其中高达40%的工人患病长达3周或更长时间。这篇简要的综述将回顾与理解和准备这一威胁相关的基本病毒学、免疫学和流行病学信息。特别是，将审查禽流感疫苗的作用。(c)2007爱思唯尔有限公司保留所有权利。
Influenza A/H5N 1 (avian influenza) has now caused 258 human infections (as of November 13, 2006), with an approximate 50% mortality rate. Because the virus is novel in terms of antigenic type and causes infection and illness, and because humans have no pre-existing immunity, the conditions for a possible pandemic exist. Additionally, wild migratory birds appear to be spreading the virus across ever larger geographic areas, and newer clade 2 influenza A/H5N1 viruses have begun to emerge. The US Congressional Budget Office has formally modeled the likely consequences of pandemic influenza and estimates that up to 2 million of the US population might die, with up to 40% of all workers ill for as long as 3 or more weeks. This brief overview will review basic virologic, immunologic and epidemiologic information relevant to understanding and preparing for this threat. In particular, the role of avian influenza vaccines will be reviewed. (c) 2007 Elsevier Ltd. All rights reserved.