Sudden Sensorineural Hearing Loss Due to Drug Abuse
Sudden Sensorineural Hearing Loss Due to Drug Abuse
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DOI：
10.1055/s-0032-1315724
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发表时间：
2012-08-01
影响因子：
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通讯作者：
Ishiyama, Gail
中科院分区：
文献类型：
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作者：
Lopez, Ivan A.;Ishiyama, Akira;Ishiyama, Gail
在过去的10年里，出现了与阿片类药物诱发的突发性感音神经性耳聋(SSNHL)相关的报道。潜在的病理机制还不完全清楚，这些药物在内车的作用机制(S)还有待确定。由于滥用阿片肽和其他药物而导致的SSNHL报告表明，内耳的阿片系统受到影响。对听觉功能的可逆或不可逆影响取决于所用药物的类型和其他几个因素，包括接触药物的时间和时间以及吸毒者的健康状况。滥用氢可酮+对乙酰氨基酚(维柯丁(R)氢可酮/扑热息痛；雅培实验室，伍斯特，马萨诸塞州)已导致几个人永久性听力丧失。相比之下，滥用海洛因导致的听力损失有时是可逆的。内源性阿片肽及其受体在内耳的广泛表达和生理作用，提示药物所致听力损失的药物治疗是可能的。本文综述了阿片类药物及其受体的基本概念，提供了阿片类药物和相关药物引起的听力损失的临床实例，综述了阿片类药物及其受体存在于内耳的实验证据(动物模型和人类研究)，并描述了阿片类药物和其他娱乐药物影响的细胞靶点。
In the last 10 years, there has been an emergence of reports related to opioid-induced sudden sensorineural hearing loss (SSNHL). The underlying pathology is not completely understood, and the mechanism(s) of action of these drugs in the inner car remains to be determined. Reports of SSNHL due to the abuse of opioid peptides and other drugs suggest that the opioid system in the inner ear is affected. The reversible or irreversible effect on auditory function depends on the type of drug used and several other factors, including duration and time of exposure as well as the health status of drug users. Abuse of hydrocodone + acetaminophen (Vicodin (R) hydrocodone/paracetamol; Abbott Laboratories, Worcester, MA) has induced permanent hearing loss in several individuals. In contrast, abuse of heroin-induced hearing loss that was sometimes reversible. The widespread expression and physiological action of endogenous peptide opioids and their receptors in the inner ear suggests that pharmacological treatment for drug-induced hearing loss is possible. The present study reviews the basic concepts of opioids and their receptors, provides clinical examples of hearing loss mediated by opioids and related drugs, reviews experimental evidence of the presence of opioids and their receptors in the inner ear (animal models and human studies), and describes the cellular targets affected by opioids and other recreational drugs.