Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD study
Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD study
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DOI：
10.1007/s00774-018-0981-5
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发表时间：
2019-09-01
影响因子：
3.3
通讯作者：
Yoshimura, Noriko
中科院分区：
文献类型：
--
作者：
Horii, Chiaki;Asai, Yoshiki;Yoshimura, Noriko
椎体骨折（VF）是一种常见的骨质疏松性骨折，其流行病学因地区和种族而异，但在日本对此知之甚少。使用基于人群的队列研究（骨关节炎/骨质疏松症抗残疾研究第三次调查）的全脊柱 X 光片，我们估计了日本人中不同性别和年龄的心室颤动患病率。采用Genant半定量法（SQ）定义VF； SQ >= 1 为心室颤动，SQ = 1 为轻度心室颤动，SQ >= 2 为重度心室颤动。我们还揭示了准确的特定地点患病率以及轻度和重度心室颤动的相关因素。参与者包括 506 名男性 [平均年龄 66.3 岁，标准差 (SD)：13.0] 和 1038 名女性（平均年龄 65.3 岁，SD：12.6）。 40 岁以下、40 岁、50 岁、60 岁、70 岁和 80 岁以上参与者中，男性 VF 患病率分别为 17.4%、7.9%、18.5%、25.6%、26.3% 和 41.5%，男性为 2.9%、2.4%、7,3、10.3、27.1%、27.1%。女性分别为 53.0%。男性轻度心室颤动的患病率 (21.2%) 显着高于女性 (10.0%, p < 0.001)；然而，严重心室颤动在女性中的发病率 (9.1%) 明显高于男性 (4.7%，p = 0.003)。 VF 根据位点分布有 2 个峰；一个大峰位于胸腰段，另一个大峰位于胸椎中部病变处。在调整参与者特征后，腰痛和行走能力下降与严重心室颤动独立相关，但与轻度心室颤动无关。女性步行能力下降与多次室颤有关，但男性则不然。
Vertebral fracture (VF) is a common osteoporotic fracture, while its epidemiology varies according to regions and ethnicities, little is known about it in Japan. Using whole-spine radiographs from a population-based cohort study, the Research on Osteoarthritis/Osteoporosis Against Disability study 3rd survey performed in 2012-2013, we estimated the sex- and age-specific prevalence of VF in the Japanese. Genant's semiquantitative method (SQ) was used to define VF; SQ >= 1 as VF, SQ = 1 as mild VF, SQ >= 2 as severe VF. We also revealed accurate site-specific prevalence, and associated factors with mild and severe VF. The participants were 506 men [mean age 66.3 years, standard deviation (SD):13.0] and 1038 women (mean age 65.3 years, SD: 12.6). The prevalence of VF in participants aged under 40, in their 40s, 50s, 60s, 70s, and >= 80 years was 17.4, 7.9, 18.5, 25.6, 26.3, and 41.5%, respectively, in men, and 2.9%, 2.4%, 7,3, 10.3, 27.1, and 53.0%, respectively, in women. Men had a significantly higher prevalence of mild VF (21.2%) than women (10.0%, p < 0.001); whereas, severe VF was significantly more prevalent in women (9.1%) than in men (4.7%, p = 0.003). VF was distributed with 2 peaks regarding site; one large peak at the thoracolumbar region, and another at the middle thoracic lesion. Low back pain and decreased walking ability were independently associated with severe VF, but not with mild VF, after adjustment for participant characteristics. Decreased walking ability was associated with multiple VFs in women, but not in men.