Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats.
Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats.
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大鼠妊娠早期棉酚治疗后子宫的组织病理学变化。
DOI：
10.1002/ar.1092130110
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Walton,A
中科院分区：
文献类型：
--
作者：
Rikihisa,Y;Lin,YC;Walton,A
通过光学和电子显微镜测定，肌内注射醋酸棉酚（从动情间期第 2 天开始，每天 25 毫克，溶于 10% EtOH/kg）会破坏大鼠的早期妊娠。与妊娠对照组一样，在妊娠第 3-5 天，治疗组大鼠的子宫内腺体分泌增加、基质充血和蜕膜组织形成。第6天，发育良好的蜕膜组织周围出现极度充血和间质出血，并伴有粘膜表面裸露的病灶。血液外渗到子宫腔内，而对照组则没有这种情况。在怀孕第 5 天和第 6 天，电子显微镜显示，与对照子宫相比，治疗组子宫腺细胞上的微绒毛更短、更少。管腔上皮细胞没有经历妊娠期的正常变化。这些结果表明，在我们的条件下施用棉酚既不会阻止也不会延迟大鼠子宫内膜中蜕膜组织的着床和形成，但子宫内膜的持续发育在妊娠第6天被破坏。这种妊娠中断可能是由于棉酚的黄体分解作用造成的，棉酚的黄体分解作用不允许大鼠子宫在着床后发生完全的结构分化。
Intramuscular injections of gossypol acetic acid (25 mg in 10% EtOH/kg/day beginning on day 2 of diestrus) disrupted early pregnancy in rats as determined by light and electron microscopy. As in pregnant controls, in the uteri of treated rats increased glandular secretion, stromal hyperemia, and decidual tissue formation were noted at days 3–5 of pregnancy. At day 6, extreme hyperemia and stromal hemorrhage had occurred around well‐developed decidual tissue with foci of denuded mucosal surface. There was extravasation of blood into the uterine lumen, which was absent in controls. At days 5 and 6 of pregnancy, electron microscopy revealed shorter and fewer microvilli on the uterine glandular cells in the treated versus the control uterus. Luminal epithelial cells had not undergone the normal changes of pregnancy. These results imply that gossypol administered under our conditions neither prevented nor delayed implantation and formation of decidual tissue in the rat uterine endometrium but continuing development of the endometrium was disrupted at day 6 of pregnancy. This disruption of pregnancy may have resulted from a luteolytic action by gossypol that would not permit full structural differentiation in the rat uterus after implantation.