A mathematical model of pH(i) regulation in central CO2- chemoreception.
A mathematical model of pH(i) regulation in central CO2- chemoreception.
复制标题
中枢 CO2 化学感受 pH(i) 调节的数学模型。
DOI：
10.1007/978-0-387-73693-8_53
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发表时间：
2008
影响因子：
--
通讯作者：
Solomon,IreneC
中科院分区：
文献类型：
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作者：
Cordovez,JuanM;Clausen,Chris;Moore,LeonC;Solomon,IreneC
在CO2化学敏感性神经元中，CO2增加（高碳酸血症）导致细胞内pH（pHi）持续降低，而在非化学敏感性神经元中观察到pH恢复。这些细胞群体之间的pHi恢复的差异调节的精确机制仍有待确定;然而，研究已经开始探索Na+/H+交换（NHE）的作用。在这里，我们比较了两种不同配方的数学模型的结果，开始探索中央CO2化学感受的pH调节。
In CO2chemosensitive neurons, an increase in CO2(hypercapnia) leads to a maintained reduction in intracellular pH (pHi) while in non-chemosensitive neurons pHirecovery is observed. The precise mechanisms for the differential regulation of pHirecovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHiregulation in central CO2chemoreception.