THE DELTA-AMINOLEVULINATE DEHYDRATASE POLYMORPHISM - HIGHER BLOOD LEAD LEVELS IN LEAD WORKERS AND ENVIRONMENTALLY EXPOSED CHILDREN WITH THE 1-2 AND 2-2 ISOZYMES
THE DELTA-AMINOLEVULINATE DEHYDRATASE POLYMORPHISM - HIGHER BLOOD LEAD LEVELS IN LEAD WORKERS AND ENVIRONMENTALLY EXPOSED CHILDREN WITH THE 1-2 AND 2-2 ISOZYMES
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DOI：
10.1016/s0013-9351(05)80001-5
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发表时间：
1991-12-01
影响因子：
8.3
通讯作者：
DESNICK, RJ
中科院分区：
文献类型：
--
作者：
WETMUR, JG;LEHNERT, G;DESNICK, RJ
在德国 202 名铅工厂工人和纽约 1278 名环境暴露儿童中测定了红细胞 δ-氨基乙酰丙酸脱水酶 (ALAD) 同工酶表型和血铅水平，这些儿童的游离原卟啉水平升高。在这两个人群中，具有 ALAD 1-2 或 2-2 同工酶表型的个体的血铅水平在统计学上高于具有 ALAD 1-1 同工酶表型的个体（铅工人：P> 0.004；儿童：P> 0.0001）。表达 2-2 或 1-2 同工酶表型的 ALAD2 等位基因纯合子和杂合子的中位血铅水平比类似暴露的 ALAD1 等位基因纯合子个体高约 9 至 11 μg/dl。这些发现支持这样的假设：ALAD2 多肽更有效地结合铅，因此具有 ALAD2 等位基因的个体可能更容易受到铅中毒的影响
The erythrocyte δ-aminolevulinate dehydratase (ALAD) isozyme phenotypes and the blood lead levels were determined in a population of 202 lead factory workers in Germany and an environmentally exposed population of 1278 children in New York who had elevated free protoporphyrin levels. In both populations, individuals with the ALAD 1–2 or 2-2 isozyme phenotype had levels of blood lead statistically higher than those individuals with the ALAD 1-1 isozyme phenotype (lead workers:P> 0.004; children:P> 0.0001). Homozygotes and heterozygotes for the ALAD2allele who expressed the 2-2 or 1–2 isozyme phenotype had median blood lead levels that were about 9 to 11 μg/dl greater than similarly exposed individuals who were homozygous for the ALAD1allele. These findings support the hypothesis that the ALAD2 polypeptide binds lead more effectively, and therefore that individuals with the ALAD2allele may be more susceptible to lead poisoning