A novel sunscreen agent having antimelanoma activity.
A novel sunscreen agent having antimelanoma activity.
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DOI：
10.1016/s0014-827x(03)00195-2
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发表时间：
2003-11-01
期刊：
影响因子：
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通讯作者：
Marsaioli, Anita J.
中科院分区：
文献类型：
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作者：
Nogueira, Marisa A.;Magalhaes, Eva G.;Marsaioli, Anita J.
通过对商品二苯甲酰甲烷衍生化，合成了一系列具有防晒和细胞毒活性的八种二苯甲酰甲烷衍生物。将四种人癌细胞系（MCF 7（乳腺）、NCI ADR（表达多药耐药表型的乳腺）、NCI 460（肺）和UACC 62（黑色素瘤））用于细胞毒性测定。19种二苯甲酰甲烷衍生物中有8种对这4种细胞系具有细胞毒性。吸收光谱显示这些化合物可用作抗紫外线辐射的防晒霜。
A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.