Differential effects of delta9-THC on learning in adolescent and adult rats
Differential effects of delta9-THC on learning in adolescent and adult rats
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DOI：
10.1016/j.pbb.2006.03.006
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发表时间：
2006-03-01
影响因子：
3.6
通讯作者：
Swartzwelder, H. S.
中科院分区：
文献类型：
--
作者：
Cha, Young May;White, Aaron M.;Swartzwelder, H. S.
在美国的年轻用户中，玛丽安娜的使用率仍然非常高，然而，很少有研究评估了δ（9）-四氢大麻酚（THC）对青少年与成人相比的影响。本研究在Morris水迷宫中测量了THC对雄性青春期和成年大鼠的影响。在实验1中，青少年（PD=30-32）和成年（PD=65-70）大鼠用5.0 mg/kg THC或溶剂急性处理，同时连续五天在水迷宫的空间版本上训练。在实验2中，青春期和成年大鼠在水迷宫的空间和非空间版本训练时，接受2.5或10.0 mg/kg THC或溶剂的急性治疗。在实验3中，青少年和成年大鼠每天用5.0 mg/kg THC或溶剂处理21天，并在没有THC的情况下训练空间和非空间版本的水迷宫任务4周后。在所有测试剂量下，THC对青少年的空间和非空间学习能力的损害均大于成年人。然而，在先前暴露于THC 21天的大鼠中，无论是空间还是非空间学习都没有持久的显着影响。这种发育敏感性类似于另一种常用的娱乐性药物乙醇的影响。(c)2006爱思唯尔公司All rights reserved.
Marijuana use remains strikingly high among young users in the U.S., and yet few studies have assessed the effects of delta(9)-tetrahydrocannabinol (THC) in adolescents compared to adults. This study measured the effects of THC on male adolescent and adult rats in the Morris water maze. In Experiment 1, adolescent (PD=30-32) and adult (PD=65-70) rats were treated acutely with 5.0 mg/kg THC or vehicle while trained on the spatial version of the water maze on five consecutive days. In Experiment 2, adolescent and adult rats were treated acutely with 2.5 or 10.0 mg/kg THC or vehicle while trained on either the spatial and non-spatial versions of the water maze. In Experiment 3, adolescent and adult rats were treated with 5.0 mg/kg THC or vehicle daily for 21 days, and were trained on the spatial and then the non-spatial versions of the water maze task four weeks later in the absence of THC. THC impaired both spatial and nonspatial learning more in adolescents than in adults at all doses tested. However, there were no long-lasting significant effects on either spatial or non-spatial learning in rats that had been previously exposed to THC for 21 days. This developmental sensitivity is analogous to the effects of ethanol, another commonly used recreational drug. (c) 2006 Elsevier Inc. All rights reserved.