Functional Properties of Human Primary Motor Cortex Gamma Oscillations
Functional Properties of Human Primary Motor Cortex Gamma Oscillations
复制标题
DOI：
10.1152/jn.00607.2010
复制
发表时间：
2010-11-01
影响因子：
2.5
通讯作者：
Muthukumaraswamy, Suresh D.
中科院分区：
文献类型：
--
作者：
Muthukumaraswamy, Suresh D.
穆图库马拉斯瓦米 SD。人类初级运动皮层伽玛振荡的功能特性。 《神经生理学杂志》104：2873-2885，2010 年。首次发表于 2010 年 9 月 8 日； doi：10.1152/jn.00607.2010。人类初级运动皮层（M1）中的伽马振荡已在人类皮层电图和无创脑磁图（MEG）/脑电图记录中得到描述，但它们在感觉运动系统中的功能意义仍然未知。在此描述的一组四个 MEG 实验中，阐明了这些振荡的许多特性。首先，伽玛振荡被 MEG 可靠地定位在 M1 中，并在肌电图发作后 137 毫秒达到峰值振幅，并且不受运动是提示还是自定进度的影响。研究发现，较大运动时伽马振荡更强，但在等长运动的持续部分不存在，没有手指运动或肌肉缩短。在重复运动序列期间，序列的第一个运动的伽马振荡更大。最后，与具有相似运动学特性的主动收缩相比，在手指被动缩短期间不存在伽马振荡，这表明 M1 振荡不仅仅与体感反馈相关。这种组合的结果模式与伽马振荡在运动控制的相对较晚阶段发挥作用是一致的，伽马振荡编码与肢体运动而不是肌肉收缩相关的信息。
Muthukumaraswamy SD. Functional properties of human primary motor cortex gamma oscillations. J Neurophysiol 104: 2873-2885, 2010. First published September 8, 2010; doi:10.1152/jn.00607.2010. Gamma oscillations in human primary motor cortex (M1) have been described in human electrocorticographic and noninvasive magnetoencephalographic (MEG)/electroencephalographic recordings, yet their functional significance within the sensorimotor system remains unknown. In a set of four MEG experiments described here a number of properties of these oscillations are elucidated. First, gamma oscillations were reliably localized by MEG in M1 and reached peak amplitude 137 ms after electromyographic onset and were not affected by whether movements were cued or self-paced. Gamma oscillations were found to be stronger for larger movements but were absent during the sustained part of isometric movements, with no finger movement or muscle shortening. During repetitive movement sequences gamma oscillations were greater for the first movement of a sequence. Finally, gamma oscillations were absent during passive shortening of the finger compared with active contractions sharing similar kinematic properties demonstrating that M1 oscillations are not simply related to somatosensory feedback. This combined pattern of results is consistent with gamma oscillations playing a role in a relatively late stage of motor control, encoding information related to limb movement rather than to muscle contraction.