Suicide gene transduced T-cells for the regulation of the graft-versus-leukemia effect
Suicide gene transduced T-cells for the regulation of the graft-versus-leukemia effect
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DOI：
10.1111/j.1423-0410.1998.tb05440.x
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发表时间：
1998-01-01
期刊：
影响因子：
2.7
通讯作者：
Bordignon, C
中科院分区：
文献类型：
--
作者：
Bonini, C;Ciceri, F;Bordignon, C
在同种异体骨髓移植（BMT）中，供体淋巴细胞在移植物抗白血病和免疫重建中起着中心治疗作用。然而，它们的使用受到严重移植物抗宿主病（GVHD）风险的限制。已经研究了不同的策略来获得来自供体淋巴细胞的所有益处，同时避免GVHD的风险。在第一项初步研究中，输注带有单纯疱疹病毒胸苷激酶（HSV-tk）自杀转导的供体淋巴细胞导致50%的患者具有抗肿瘤活性。通过更昔洛韦诱导消除转导细胞可有效控制急性GVHD。如果这些结果在更大规模的研究中得到证实，对供体淋巴细胞进行基因操作将提高同种异体骨髓移植的疗效和安全性。
In allogeneic marrow transplantation (BMT), donor lymphocytes play a central therapeutic role in both graft-versus-leukemia and immune reconstitution. However, their use is limited by the risk of severe graft-vs-host disease (GVHD). Different strategies have been investigated to obtain all the benefits derived from donor lymphocytes while avoiding the risk of GVHD. In the first pilot study, infusions of donor lymphocytes transduced with the Herpes Simplex virus thymidine kinase (HSV-tk) suicide resulted in anti-tumor activity in 50% of patients. Acute GVHD could be effectively controlled by ganciclovir-induced elimination of the transduced cells. If these results will be confirmed in larger studies, genetic manipulation of donor lymphocytes will increase efficacy and safety of allogeneic marrow transplantation.