Muscle MRI of facioscapulohumeral dystrophy (FSHD): A growing demand and a promising approach
Muscle MRI of facioscapulohumeral dystrophy (FSHD): A growing demand and a promising approach
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DOI：
10.1016/j.neurol.2016.08.002
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发表时间：
2016-10-01
影响因子：
3
通讯作者：
Attarian, S.
中科院分区：
文献类型：
--
作者：
Fatehi, F.;Salort-Campana, E.;Attarian, S.
面肩肱型肌营养不良症（FSHD）是一种遗传性和进行性肌肉疾病，是最常见的遗传性肌肉疾病之一。从临床Vantage来看，FSHD的特征是面部、肩部（通常伴有肩胛翼）、手臂（包括二头肌和三头肌）和腹部肌肉的无力。前臂肌肉通常是备用和弱点通常是不对称的。在过去的几十年里，肌肉磁共振成像（MRI）已成为一种可靠和准确的非侵入性工具，用于诊断和评估神经肌肉疾病的进展，显示了一些肌病肌肉受累的特定模式。最近，MRI已被用于非侵入性地识别定量生物标志物，允许评估疾病的自然进展和评估治疗干预。在本综述中，目的是介绍与FSHD诊断和模式识别相关的最重要的MRI发展，并讨论其提供结局指标的能力。(C)2016 Elsevier Masson SAS。All rights reserved.
Facioscapulohumeral muscular dystrophy (FSHD), an inherited and progressive muscle disorder, is among the most common hereditary muscle disorders. From a clinical vantage point, FSHD is characterized by weakness of the facial, shoulder (often with scapular winging), arm (including biceps and triceps) and abdominal muscles. Forearm muscles are usually spared and weakness is usually asymmetrical. Over the past few decades, muscle magnetic resonance imaging (MRI) has become established as a reliable and accurate noninvasive tool for the diagnosis and assessment of progression in neuromuscular diseases, showing specific patterns of muscle involvement for a number of myopathies. More recently, MRI has been used to noninvasively identify quantitative biomarkers, allowing evaluation of the natural progression of disease and assessment of therapeutic interventions. In the present review, the intention was to present the most significant MRI developments related to diagnosis and pattern recognition in FSHD and to discuss its capacity to provide outcome measures. (C) 2016 Elsevier Masson SAS. All rights reserved.