β-Trace protein -: A marker of kidney function in children:: "Original research communication-clinical investigation"
β-Trace protein -: A marker of kidney function in children:: "Original research communication-clinical investigation"
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DOI：
10.1016/j.clinbiochem.2007.05.003
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发表时间：
2007-09-01
影响因子：
2.8
通讯作者：
Stoffel-Wagner, Birgit
中科院分区：
文献类型：
--
作者：
Boekenkamp, Arend;Franke, Ingo;Stoffel-Wagner, Birgit
目的：确定儿童血清β -微量蛋白（β - tp）的参考区间，并将β - tp与已建立的GFR LMW标志物，即胱抑素C （CysC）和β(2)-微球蛋白（β 2- m）进行比较。设计与方法：采用免疫比浊法测定三种LMW标记物。在106名2岁以上无肾脏疾病证据的儿童中，计算非参数参考区间。在覆盖整个GFR范围的96例患者的107个样本中，研究了GFR标记物浓度高于上参考值的相对上升。结果：2年以上β - tp的参考范围为0.43 ~ 1.04 mg/L。随着Schwartz-GFR的降低，β - tp和β (2)- m升高，而GFR低于30 mL/min/1.73 m(2)组的CysC升高较少(278 +/- 49% [CysC]， 336 +/- 65% [β - tp]和342 +/- 76% [β (2)- m]；P分别= 0.043和0.027)。结论：这些数据证实了β - tp作为儿童内源性GFR标志物的潜力。(c) 2007加拿大临床化学家学会。Elsevier Inc.出版。版权所有。
Objectives: To determine the pediatric reference interval for serum beta-trace protein (beta-TP) and to compare beta-TP with established LMW markers of GFR, i.e., cystatin C (CysC) and beta(2)-mnicroglobulin (beta 2-M).Design and methods: All three LMW markers were measured immunonephelometrically. In 106 children above the age of 2 years without evidence of kidney disease, non-parametric reference intervals were calculated. The relative rise of the GFR marker concentrations above the upper reference was studied in 107 samples from 96 patients covering the entire GFR range.Results: Above 2 years, the reference range of beta-TP was constant at 0.43-1.04 mg/L. With decreasing Schwartz-GFR, there was a comparable rise in beta-TP and beta(2)-M, while CysC rose less in the group with GFR below 30 mL/min/1.73 m(2) (278 +/- 49% [CysC] versus 336 +/- 65% [beta-TP] and 342 +/- 76% [beta(2)-M]; p = 0.043 and 0.027, respectively).Conclusions: These data confirm the potential of beta-TP as an endogenous GFR marker in children. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.