Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults.
Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults.
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DOI：
10.1371/journal.pone.0175800
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Osaka University Twin Research Group
中科院分区：
文献类型：
--
作者：
Lukies MW;Watanabe Y;Tanaka H;Takahashi H;Ogata S;Omura K;Yorifuji S;Tomiyama N;Osaka University Twin Research Group
脑萎缩是衰老过程的一部分，并由神经退行性疾病加速，因此了解脑容量的背景遗传性是必不可少的。本研究的目的是确定大脑容量的遗传性在中年到老年东亚成年人，一个年龄组研究较少，以前没有研究过的种族。共获得74个个体的3T磁共振图像并进行体积分析，其中20对单卵双胞胎对（平均年龄61岁最小41岁最大75岁）和17对双卵双胞胎对（平均年龄64岁最小41岁最大85岁）。评估了总脑体积和另外七个区域，包括脑叶体积、侧分区和分离的灰质和白色物质。加性遗传学和独特的环境（AE）模型的全球脑体积，包括全脑（90%），灰质（91%）和白色物质（84%）和许多脑叶体积在我们的研究人群中表现出高遗传性。我们的研究结果表明，东亚成年人中老年人脑容量的遗传率可能更高。
Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population. Our results present the heritability of brain volume in middle to advanced age as possibly higher in East Asian adults.