The role of the CXCL10/CXCR3 system in type 1 diabetes.
The role of the CXCL10/CXCR3 system in type 1 diabetes.
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DOI：
10.1900/rds.2009.6.81
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
A. Shimada;Y. Oikawa;Yoshifumi Yamada;Y. Okubo;S. Narumi
中科院分区：
文献类型：
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作者：
A. Shimada;Y. Oikawa;Yoshifumi Yamada;Y. Okubo;S. Narumi
尽管使用胰岛素进行干预，1型糖尿病仍会逐渐恶化患者的生活质量。该疾病的特征在于免疫介导的胰腺β细胞破坏。然而，其病因仍然存在争议。一些研究认为，谷氨酸脱羧酶（GAD）抗原和GAD反应性T细胞通过影响Th细胞平衡在糖尿病的发展中起关键作用。辅助性T细胞1（Th 1）-显性免疫应答被认为在1型糖尿病的人类和动物模型中的β细胞衰竭中是重要的。Th 1型趋化因子CXCL 10及其受体CXCR 3不仅参与免疫应答，还参与抑制β细胞增殖。因此，了解CXCL 10/CXCR 3系统可能对找到治疗方法很重要。在这篇简短的综述中，我们讨论了CXCL 10/CXCR 3系统在1型糖尿病中的作用，并提出了相关的治疗方案。
Despite intervention with insulin, type 1 diabetes gradually deteriorates the patients' quality of life. The disease is characterized by an immune-mediated destruction of pancreatic beta-cells. Its etiology, however, remains controversial. Some studies argue that glutamic acid decarboxylase (GAD) antigen and GAD-reactive T cells are critical players in the development of diabetes by affecting the Th cell balance. A T-helper 1 (Th1)-dominant immune response is considered to be important in beta-cell failure in both human and animal models of type 1 diabetes. The Th1-type chemokine, CXCL10, and its receptor, CXCR3, are involved not only in the immune response, but also in the suppression of beta-cell proliferation. Thus, understanding the CXCL10/CXCR3 system may be important for finding a cure. In this short review, we discuss the role of the CXCL10/CXCR3 system in type 1 diabetes and propose relevant treatment options.