Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury.
Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury.
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DOI：
10.2174/1570159x16666180516095949
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发表时间：
2018
影响因子：
5.3
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Li D;Ni H;Rui Q;Gao R;Chen G
哺乳动物STE20样激酶-1(Mst1)是一种普遍表达的促凋亡蛋白，在组织损伤的病因学中是凋亡信号的关键桥梁。然而，尽管Mst1的生物学功能及其在细胞信号网络中的作用尚未确定，但有大量证据表明，Mst1在组织损伤引起的细胞死亡中发挥着重要作用。以往的研究表明，Mst1不仅是caspase-3、p53等细胞凋亡相关分子的靶标，而且还可以作为这些蛋白的激活剂，放大细胞凋亡信号通路。本文就Mst1在心肌和脑损伤后神经细胞凋亡或小胶质细胞激活的信号通路中的作用作一综述。因此，这项工作有助于更好地了解心肌和脑损伤的病理过程。
Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridge-builder of apoptotic signaling in the etiology of tissue injury. Despite the fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be determined, however, there is a lot of evidence that Mst1 plays an important role in cell death which results from tissue injury. Previous studies have shown that Mst1 is not only a target for some apop-tosis-related molecules such as caspase 3 and P53, but also act as an activator of these proteinases to magnify apoptosis sig-nal pathways. This article reviews the role of Mst1 in the signaling pathways which is related with the neuronal cell apopto-sis or microglia activation following myocardial and brain injury. Therefore, this work contributes to better understanding of the pathological process of myocardial and brain injury