MATURATION OF GLOMERULAR VISCERAL EPITHELIUM AND CAPILLARY ENDOTHELIUM IN PUPPY KIDNEY
MATURATION OF GLOMERULAR VISCERAL EPITHELIUM AND CAPILLARY ENDOTHELIUM IN PUPPY KIDNEY
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DOI：
10.1002/ar.1091930102
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
EVAN, AP
中科院分区：
文献类型：
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作者：
HAY, DA;EVAN, AP
描述肾小球内脏上皮和毛细血管内皮的发育和成熟，试图阐明新生儿的肾功能。幼犬肾脏在出生后至少2周内经历肾发生，因此具有不同年龄和成熟程度的肾单位。由于肾单位发育从内皮质到外皮质有很大差异，因此在 3 个任意区域（外皮质、中皮质和内皮质）内检查肾小体。最小肾小球（即外皮层）的内脏上皮由密集聚集的立方形细胞组成，直接位于毛细血管周围延伸的有限数量的突起上，但没有任何可见的蒂。中皮质肾小球毛细血管的直径和长度增加，同时足细胞变平并彼此分离。花梗开始在该区域出现，表现为增厚、杂乱的突起。近髓肾小球最大，主要是由于其广泛的毛细血管分支（环状）。足细胞的外观几乎与成体相似，具有许多长的初级突起和花梗。肾小球毛细血管的内皮形态从一个环到另一个环以及在单个环内都不同。外肾小球的未成熟内皮最初的特征是大范围缺乏孔、多个细胞层和小而分散的针孔。由于孔隙数量和直径的增加以及内皮细胞的更大程度的衰减，中皮层毛细血管的成熟度明显提高。一些毛细血管中仍然存在重塑和缺乏毛孔的证据。内皮质的肾小球毛细血管似乎最成熟，但与成人相比，其部分区域仍不成熟。
The development and maturation of the glomerular visceral epithelium and capillary endothelium are described in an attempt to clarify kidney function in the neonate. The puppy kidney undergoes nephrogenesis for at least 2 wk after birth, and thus possesses nephrons of different ages and levels of maturation. Since nephron development varies considerably from inner to outer cortex, renal corpuscles were examined within 3 arbitrary zones (outer, middle and inner cortex). The visceral epithelium of the smallest glomeruli, i.e., those of the outer cortex, is composed of cuboidal cells which are densely clustered and rests directly upon the limited number of processes extend around the capillary, but lack any visible pedicels. Mid cortical glomerular capillaries undergo an increase in diameter and length, and at the same the podocytes flatten and separate from one another. Pedicels begin to appear in this zone as thickened, disorganized processes. Juxtamedullary glomeruli are the largest, due primarily to their extensive capillary branching (looping). Podocytes are nearly adult-like in appearance, with many long primary processes and pedicels. The endothelial morphology of glomerular capillaries varies from one loop to another, as well as within a single loop. The immature endothelium of outer glomeruli is initially characterized by extensive expanses lacking pores, multiple cellular layers and small, scattered pinholes. Greater capillary maturity is apparent in the mid cortex, due to an increase in pore number and diameter as well as greater attenuation of endothelial cells. Evidence of remodeling and a lack of pores still exists in some capillaries. The glomerular capillaries of the inner cortex appear the most mature, but possess regions that are still immature when compared to the adult.