Association between body mass index and endometriosis risk: a meta-analysis
Association between body mass index and endometriosis risk: a meta-analysis
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DOI：
10.18632/oncotarget.14916
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发表时间：
2017-07-18
期刊：
影响因子：
--
通讯作者：
Zhang, Weiyuan
中科院分区：
文献类型：
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作者：
Liu, Yong;Zhang, Weiyuan
背景：流行病学研究试图确定女性目前的体重指数与子宫内膜异位症之间的关系，但结果各不相同。本Meta分析旨在总结当前的流行病学证据。方法：通过检索PubMed和Web of Science确定相关研究至2016年11月。根据是否检测到显著的异质性，使用固定或随机效应模型合并特定研究的风险估计。结果：共有11项研究(2项队列研究和9项病例对照研究)进入荟萃分析。当前体重指数每增加5 kg/m(2)，合并的子宫内膜异位症的相对风险为0.67(95%CI：0.53，0.84)，在所有研究中具有统计学意义的异质性(P<；0.001，I-2=86.9%)。与正常体重妇女相比，肥胖妇女合并相对危险度为0.89(95%CI：0.83，0.96)，低于超重妇女(相对危险度=0.97；95%CI：0.91，1.05)。联合估计在亚组和敏感性分析中是稳健的，没有发现观察到的发表偏倚。结论：这项研究表明，较高的体重指数可能与较低的子宫内膜异位症风险相关。进一步的工作需要集中于阐明导致子宫内膜异位症发生的潜在生物学机制。
Background: Epidemiological studies have sought to establish a relationship between a woman's current body mass index and endometriosis, but with varying results. This meta-analysis was to summarize the current epidemiological evidence.Methods: Pertinent studies were identified by searching PubMed and Web of Science through November 2016. Study-specific risk estimates were combined using fixed or random effects models depending on whether significant heterogeneity was detected.Results: A total of 11 studies (two cohort studies and nine case-control studies) was included in the meta-analysis. The pooled relative risk of endometriosis was 0.67 (95% CI: 0.53, 0.84) for each 5 kg/m(2) increase in current body mass index, with statistical significant heterogeneity across the studies (P < 0.001, I-2 =86.9%). Compared with normal weight women, the pooled relative risk for obese women was 0.89 (95% CI: 0.83, 0.96), which was lower than that for overweight women (relative risk =0.97; 95% CI: 0.91, 1.05). The combined estimate was robust across subgroup and sensitivity analyses and no observed publication bias was detected.Conclusion: This study suggested that higher body mass index may be associated with lower risk of endometriosis. Further work will need to focus on elucidating underlying biologic mechanism that contribute to the initiation of endometriosis.