Correlation between intraocular pressure, central corneal thickness, stage of glaucoma, and demographic patient data -: Prospective analysis of biophysical parameters in tertiary glaucoma practice populations
Correlation between intraocular pressure, central corneal thickness, stage of glaucoma, and demographic patient data -: Prospective analysis of biophysical parameters in tertiary glaucoma practice populations
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DOI：
10.1097/00061198-200604000-00003
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发表时间：
2006-04-01
影响因子：
2
通讯作者：
Stamper, RL
中科院分区：
文献类型：
--
作者：
Kniestedt, C;Lin, S;Stamper, RL
目的：探讨角膜中央厚度（CCT）与Goldmann压平眼压（GAT）、动态等高线眼压（DCT, PASCAL (R)）及杯盘比（CDR）评定青光眼分期的相关性。设计：前瞻性、横断面三中心观察研究。患者和方法：从三家青光眼专科医院中选取406只独立眼。超声测厚后，采用PASCAL (R)和Goldmann压平眼压计测量眼压，并重新评估夹盘比。人口统计数据被纳入多变量分析。结果：平均角膜厚度为540针。非裔美国人和正常眼压青光眼患者最低（分别为518 mu m和522 mu m）。这些值明显薄于白种人（549 mu m）和高眼压患者（564 mu m）的角膜中央厚度。Goldmann压平眼压计测得的眼压与角膜中央厚度有显著相关性（r(2) = 0.068, P < 0.001），而PASCAL (r)与角膜中央厚度无显著相关性（r(2) < 0.001, P = 0.997）。IOP升高与大眼脉冲幅值显著相关（r(2) = 0.13, P < 0.001），主要见于高眼压患者。杯盘比与角膜中央厚度呈显著负相关（r(2) = 0）。102, p < 0。001)。结论：青光眼中心角膜厚度薄的患者更容易在疾病的晚期、正常眼压青光眼和非洲黑人祖先中被发现。Goldmann眼压计低估眼压可能是一个致病因素。
Purpose: To determine the correlation of central corneal thickness (CCT) to Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT, PASCAL (R)), and to glaucoma stage as assessed by cup-to-disc ratio (CDR).Design: Prospective, cross-sectional tricenter observation study.Patients and Methods: From three glaucoma specialty practices a sample of 406 independent eyes was included. After ultrasound pachymetry, intraocular pressure was measured using PASCAL (R) and Goldmann applanation tonometry and Clip-to-disc ration was reassessed. Demographic data were included in the multivariate analysis.Results: Mean corneal thickness was 540 pin. African Americans and normal-tension glaucoma patients showed the lowest values (518 mu m and 522 mu m, respectively). These values were significantly thinner than the central corneal thickness of Caucasians (549 mu m) and Ocular hypertensives (564 mu m). Intraocular pressure assessed by Goldmann applanation tonometry shows a significant correlation with central corneal thickness (r(2) = 0.068, P < 0.001), whereas PASCAL (R) is not significantly associated with central corneal thickness (r(2) < 0.001, P = 0.997). Increased IOP is significantly correlated with large ocular pulse amplitudes (r(2) = 0.13, P < 0.001), which is predominantly seen in ocular hypertensives. A significant negative correlation was detected between cup-to-disc ratio and central corneal thickness (r(2) = 0. 102, P < 0. 001).Conclusion: Glaucoma patients with thin central corneal thickness are more likely to be found at an advanced stage of the disease and among those with normal-tension glaucoma and black African ancestry. Underestimation of intraocular pressure by Goldmann applanation tonometry could be one causative factor.