Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized 129Xe MR
Single breath-hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized 129Xe MR
复制标题
使用超极化 129Xe MR 对人体肺部气体交换和扩散进行单次屏气测量
DOI：
10.1002/nbm.4068
复制
发表时间：
2019
影响因子：
2.9
通讯作者：
Zhou Xin
中科院分区：
文献类型：
--
作者：
Xie Junshuai;Li Haidong;Zhang Huiting;Zhao Xiuchao;Shi Lei;Zhang Ming;Xiao Sa;Deng He;Wang Ke;Yang Hao;Sun Xianping;Wu Guangyao;Ye Chaohui;Zhou Xin
肺部疾病通常在早期阶段导致血气交换功能的改变。通过化学位移饱和恢复（CSSR）和扩散加权成像（DWI），可以使用超极化129 μ M MR分别量化跨呼吸膜的气体交换和肺泡中的气体扩散。一般来说，CSSR和DWI数据是在人类的单独呼吸中收集的。不幸的是，在不同的呼吸中，肺充气水平不可能完全相同，这会导致血气交换和肺微观结构的波动。在这里，我们结合联合收割机CSSR和DWI获得的压缩传感，以评估气体扩散和交换功能，在一个单一的屏住呼吸在人类。提出了一个新的参数，即呼吸膜的灌注因子（SVRd/g），来评价气体交换功能。在健康年轻人、年龄匹配的对照组和慢性阻塞性肺疾病人群队列中，将超极化129 μ M MR数据与肺功能检查和计算机断层扫描检查进行比较。SVRd/g随通气功能障碍和肺气肿指数的增加而降低。我们的研究结果表明，所提出的方法有可能检测肺实质的破坏程度所造成的年龄和肺部疾病，这将是有用的肺部疾病的早期诊断在临床实践中。
Pulmonary diseases usually result in changes of the blood‐gas exchange function in the early stages. Gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized129Xe MR via chemical shift saturation recovery (CSSR) and diffusion‐weighted imaging (DWI), respectively. Generally, CSSR and DWI data have been collected in separate breaths in humans. Unfortunately, the lung inflation level cannot be the exactly same in different breaths, which causes fluctuations in blood‐gas exchange and pulmonary microstructure. Here we combine CSSR and DWI obtained with compressed sensing, to evaluate the gas diffusion and exchange function within a single breath‐hold in humans. A new parameter, namely the perfusion factor of the respiratory membrane (SVRd/g), is proposed to evaluate the gas exchange function. Hyperpolarized129Xe MR data are compared with pulmonary function tests and computed tomography examinations in healthy young, age‐matched control, and chronic obstructive pulmonary disease human cohorts. SVRd/gdecreases as the ventilation impairment and emphysema index increase. Our results indicate that the proposed method has the potential to detect the extent of lung parenchyma destruction caused by age and pulmonary diseases, and it would be useful in the early diagnosis of pulmonary diseases in clinical practice.