Role for IL-1 Family Cytokines in Fungal Infections.
Role for IL-1 Family Cytokines in Fungal Infections.
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DOI：
10.3389/fmicb.2021.633047
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发表时间：
2021
影响因子：
5.2
通讯作者：
Naglik JR
中科院分区：
文献类型：
--
作者：
Griffiths JS;Camilli G;Kotowicz NK;Ho J;Richardson JP;Naglik JR
真菌病原体每年造成约150万人死亡，是全世界严重的疾病负担。据估计，超过1.5亿人患有严重的真菌疾病，如复发性粘膜感染或危及生命的全身感染。疾病可由共生真菌或新感染引起，涉及不同的真菌形态和毒力因子的表达。因此，抗真菌免疫是复杂的，需要免疫系统的多个方面之间的协调。IL-1家族细胞因子与急性和慢性炎症有关，对感染的先天反应至关重要。最近的研究表明，IL-1细胞因子在介导不同真菌感染的免疫中起关键作用。在粘膜疾病中，IL-1R和IL-36R是中性粒细胞募集和保护性Th17反应所必需的，但其作用机制不同。在全身性疾病中，IL-18驱动保护性Th1反应，而IL-33促进Th2并抑制Th1免疫。IL-1家族是一个有吸引力的抗真菌免疫治疗靶点。由于目前的治疗方法无效、有毒且遇到耐药性，而且没有抗真菌疫苗，因此需要新的抗真菌治疗方法。进一步了解IL-1家族细胞因子及其在真菌感染中的复杂作用可能有助于开发新的治疗方法。因此，本文将讨论IL-1家族细胞因子在真菌感染中的作用。
Fungal pathogens kill approximately 1.5 million individuals per year and represent a severe disease burden worldwide. It is estimated over 150 million people have serious fungal disease such as recurrent mucosal infections or life-threatening systemic infections. Disease can ensue from commensal fungi or new infection and involves different fungal morphologies and the expression of virulence factors. Therefore, anti-fungal immunity is complex and requires coordination between multiple facets of the immune system. IL-1 family cytokines are associated with acute and chronic inflammation and are essential for the innate response to infection. Recent research indicates IL-1 cytokines play a key role mediating immunity against different fungal infections. During mucosal disease, IL-1R and IL-36R are required for neutrophil recruitment and protective Th17 responses, but function through different mechanisms. During systemic disease, IL-18 drives protective Th1 responses, while IL-33 promotes Th2 and suppresses Th1 immunity. The IL-1 family represents an attractive anti-fungal immunotherapy target. There is a need for novel anti-fungal therapeutics, as current therapies are ineffective, toxic and encounter resistance, and no anti-fungal vaccine exists. Furthering our understanding of the IL-1 family cytokines and their complex role during fungal infection may aid the development of novel therapies. As such, this review will discuss the role for IL-1 family cytokines in fungal infections.
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影响因子：
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作者：
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