Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
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DOI：
10.1254/jphs.fpj04014x
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发表时间：
2004
影响因子：
3.5
通讯作者：
A. Saitoh;Yuji Kimura;Tomohiko Suzuki;K. Kawai;H. Nagase;J. Kamei
中科院分区：
文献类型：
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作者：
A. Saitoh;Yuji Kimura;Tomohiko Suzuki;K. Kawai;H. Nagase;J. Kamei
在本研究中，我们在啮齿动物的各种动物模型中研究了（+）-4-[（aR）-a-（（2S，5 R）-4-烯丙基-2，5-二甲基-1-哌嗪基）-3-甲氧基苄基]-N，N-二乙基苯甲酰胺（SNC 80）（一种非肽选择性δ阿片受体激动剂）的抗抑郁和抗焦虑样作用。SNC 80显著减少强迫游泳试验中的不动持续时间。此外，在高架十字迷宫测试中，SNC 80以剂量依赖性方式显着增加了在十字迷宫开放臂中花费的时间。这些作用完全拮抗的选择性δ阿片受体拮抗剂，纳曲吲哚。在条件性恐惧应激试验中，检查心理应激引起的运动抑制，地昔帕明没有产生任何显着的影响，对自发活动的条件性抑制。然而，SNC 80完全减弱了条件性恐惧应激试验中自发活动的条件性抑制。总之，我们的研究结果表明，δ阿片受体可能在情绪反应的调节中发挥重要作用。此外，δ-阿片受体激动剂可能是一种新的有效的抗抑郁药，也具有抗焦虑作用。
In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a non-peptidic selective delta-opioid receptor agonist, in various animal models in rodents. SNC80 significantly reduced the duration of immobility in the forced swimming test. Furthermore, in the elevated plus-maze test, SNC80 dose-dependently and significantly increased the time spent in the open arms of the plus-maze. These effects were completely antagonized by a selective delta-opioid-receptor antagonist, naltrindole. In the conditioned fear stress test, which examines psychological stress-induced motor suppression, desipramine did not produce any significant effect on the conditioned suppression of locomotor activity. However, SNC80 completely attenuated the conditioned suppression of locomotor activity in the conditioned fear stress test. In conclusion, our results suggest that delta-opioid receptors may play an important role in the regulation of emotional responses. Furthermore, it is possible that delta-opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects.