E2A proteins: Regulators of cell phenotype in normal physiology and disease
E2A proteins: Regulators of cell phenotype in normal physiology and disease
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DOI：
10.1016/j.biocel.2007.05.014
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发表时间：
2008-01-01
影响因子：
4
通讯作者：
McMorro, Tara
中科院分区：
文献类型：
--
作者：
Slattery, Craig;Ryan, Michael P.;McMorro, Tara
E2 A基因编码两种不同的碱性螺旋-环-螺旋转录因子E12和E47，E12和E47通过与其他碱性螺旋-环-螺旋转录因子形成同源二聚体和异源二聚体来调节其靶基因的表达。E2 A蛋白被认为在包括淋巴细胞、肌肉细胞和神经元在内的一系列细胞类型中的细胞定型、生长和分化的调节中起关键作用。新出现的证据表明，E2 A蛋白在上皮间质转化过程中也起着关键作用，这是一种显著促进肾脏疾病进展和肿瘤转移的机制。进一步了解E2 A蛋白的不同作用可能会导致新的治疗方法来靶向重要的疾病过程。(C)2007爱思唯尔有限公司保留所有权利。
The E2A gene encodes two distinct basic helix-loop-helix transcription factors, E12 and E47.E12 and E47 modulate expression of their target genes through formation of homodimers and heterodimers with other basic helix-loop-helix transcription factors. E2A proteins are thought to play critical roles in regulation of cell commitment, growth and differentiation in a range of cell types including lymphocytes, muscle cells and neurons. Emerging evidence suggests that E2A proteins also play key roles in the process of epithelial mesenchymal transition, a mechanism which contributes significantly to kidney disease progression and tumour metastasis. Further understanding of the diverse effects of E2A proteins may lead to novel therapeutic approaches to targeting important disease process. (C) 2007 Elsevier Ltd. All rights reserved.