Fabrication and characterization of dipalmitoylphosphatidylcholine-attracting elastomeric material for joint replacements.
Fabrication and characterization of dipalmitoylphosphatidylcholine-attracting elastomeric material for joint replacements.
复制标题
用于关节置换的二棕榈酰磷脂酰胆碱吸引弹性体材料的制造和表征。
DOI：
10.1016/0142-9612(95)93582-x
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发表时间：
1995
期刊：
影响因子：
14
通讯作者：
LaBerge,M
中科院分区：
文献类型：
--
作者：
Williams3rd,PF;Powell,GL;Love,B;Ishihara,K;Nakabayashi,N;Johnson,R;LaBerge,M
与全关节置换术的聚乙烯部件相关的磨损碎屑已被证明可诱导骨吸收，从而导致植入物松动。为了促进润滑和减少人工髋关节的磨损，之前已提出使用缓冲支承概念;然而，作为缓冲支承进行试验的弹性体材料已被证明在从静止开始运动期间具有较差的摩擦学特性。该项目的目标是制造和表征一种弹性体，该弹性体能够从水溶液中吸引天然存在的边界润滑剂到其表面。使用荧光、电子自旋共振和X射线光电子能谱对试验弹性体和适当对照品进行表征。发现测试弹性体具有增强的吸引二棕榈酰磷脂酰胆碱（一种已知的生理边界润滑剂）的能力。一个缓冲轴承，也鼓励边界润滑代表了一个潜在的改进，目前现有的骨科植入物轴承材料。
Wear debris associated with the polyethylene components of total joint replacements has been shown to induce bone resorption which contributes to implant loosening. In an effort to promote lubrication and reduce wear in artificial hip joints, the use of the cushion bearing concept has been proposed previously; however, an elastomeric material tested as a cushion bearing has been shown to have poor tribological properties during initiation of motion from rest. The goal of this project was to fabricate and characterize an elastomer that has the ability to attract to its surface naturally occurring boundary lubricants from an aqueous solution. The test elastomer and appropriate controls were characterized using fluorescence, electron spin resonance and X-ray photoelectron spectroscopy. The test elastomer was found to have an enhanced ability to attract dipalmitoylphosphatidylcholine, a known physiological boundary lubricant. A cushion bearing that also encourages boundary lubrication represents a potential improvement over currently existing orthopaedic implant-bearing materials.