Base sequence dependence of deoxyribonucleic acid studied by scanning tunneling microscopy
Base sequence dependence of deoxyribonucleic acid studied by scanning tunneling microscopy
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DOI：
10.1143/jjap.39.1892
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发表时间：
2000-04-01
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影响因子：
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通讯作者：
Kawai, T
中科院分区：
文献类型：
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作者：
Kanno, T;Tanaka, H;Kawai, T
为了鉴定脱氧核糖核酸(DNA)的高阶结构和节距长度，用脉冲注入法将聚(da-dt)、聚(da-dt)和聚(dg-dc)、聚(dg-dc)吸附在铜(111)衬底上，并用超高真空扫描隧道显微镜(STM)对其进行了观察。在大规模扫描隧道显微镜图像中，Poly(DC-DC)Poly(DG-DC)的高阶结构比Poly(da-DT)Poly(da-DT)具有更高的发散度和更短的维度。高分辨扫描隧道显微镜图像显示，聚(da-DT)、聚(da-dt)和聚(dg-dc)聚(dg-dc)聚(dG-DC)吸附在表面上的螺距长度比在水溶液中长。
In order to identify high-order structures and pitch length of deoxyribonucleic acid (DNA), poly(dA-dT).poly(dA-dT) and poly(dG-dC).poly(dG-dC) were adsorbed on Cu(111) substrates by the pulse injection method and were observed by ultra high vacuum (UHV) scanning tunneling microscopy (STM). In large-scale STM images, the high-order structure of poly(dC-dC)poly(dG-dC) has a higher divergence and shorter dimension compared with those of poly(dA-dT) poly(dA-dT). High-resolution STM images revealed that the pitch lengths of poly(dA-dT)poly(dA-dT) and poly(dG-dC)poly(dG-dC) adsorbed onto the surface were longer than those possessed in the aqueous solution.