Preliminary development of a physiological model for perchlorate in the adult male rat: A framework for further studies
Preliminary development of a physiological model for perchlorate in the adult male rat: A framework for further studies
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DOI：
10.1081/dct-100100113
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发表时间：
2000-01-01
影响因子：
2.6
通讯作者：
Yu, K
中科院分区：
文献类型：
--
作者：
Fisher, J;Todd, P;Yu, K
NASA和DoD使用高氯酸铵（NH4ClO4）盐作为固体火箭推进剂的氧化剂。高氯酸盐用于几种应用，如照明弹，烟火，炸药，电池和安全气囊充气机。高氯酸盐的大规模生产始于20世纪40年代。NH4ClO4是固体火箭推进剂的主要成分（70-75%）。NH4ClO4极易溶于水，完全解离成NH4+和ClO4-。由于历史上的处理方法，地表水和地下水被NH4ClO4污染的情况发生在西部的加利福尼亚州、内华达州、犹他州和亚利桑那州。1关于高氯酸铵的毒理学特性有一些信息。高氯酸铵已被用于治疗人类的格雷夫斯病。2,3格雷夫斯病导致甲状腺过度活跃，导致甲状腺功能亢进。高氯酸盐离子（ClO4-）通过抑制碘化物进入甲状腺来减缓过度活跃的甲状腺。
NASA and DoD use ammonium perchlorate (NH4ClO4) salt as an oxidizer in solid rocket propellants. Perchlorate salts are used in several applications such as flares, pyrotechnics, explosives, batteries, and air bag inflators. Large-scale production of perchlorate salts began in the 1940s. NH4ClO4 is the major ingredient (70-75%) in solid rocket propellants. NH4ClO4 is highly soluble in water and completely dissociates to NH4+ and ClO4-. Because of historical handling practices, surface water and ground water contamination with NH4ClO4 has occurred in the western states of California, Nevada, Utah and Arizona. 1 Some information is available on the toxicological properties of ammonium perchlorate. Ammonium perchlorate has been used to treat Grave's disease in humans. 2, 3 Grave's disease results in an overactive thyroid gland leading to hyperthyroidism. The perchlorate ion (ClO4-) slows an overactive thyroid gland by inhibiting the uptake of iodide into the thyroid gland.