Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion.
Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion.
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DOI：
10.3390/jcm5020020
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发表时间：
2016-02-03
影响因子：
3.9
通讯作者：
Storz P
中科院分区：
文献类型：
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作者：
Durand N;Borges S;Storz P
蛋白激酶D （PKD）异构体PKD1、PKD2和PKD3是新型蛋白激酶Cs （nPKCs）和二酰基甘油（DAG）的效应物。pkd影响多种生物过程，如蛋白质转运、细胞迁移、增殖、上皮向间质转化（EMT）和细胞凋亡。然而，pkd对这些功能有不同的影响。虽然PKD1阻断EMT和细胞迁移，但PKD2和PKD3倾向于驱动这两个过程。鉴于EMT和细胞迁移对各种恶性肿瘤的发生和发展的重要性，pkd的异常表达已在多种类型的癌症中被报道，包括乳腺癌、胰腺癌和前列腺癌。在这篇综述中，我们讨论了PKD异构体如何调节EMT和细胞迁移，以及这种调节在癌症发展中的意义。
The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development.
影响因子：
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作者：
Wang H;Zhu X;Zhu Y;Liu J;Hu X;Wang Y;Peng S;Chen Y;Chen R;Ding F;Liu R
通讯作者：
Liu R