Exposure to organochlorine pesticides and the risk of type 2 diabetes in the population of East China
Exposure to organochlorine pesticides and the risk of type 2 diabetes in the population of East China
复制标题
华东地区人群有机氯农药暴露与2型糖尿病风险
DOI：
10.1016/j.ecoenv.2019.110125
复制
发表时间：
2020-03-01
影响因子：
6.8
通讯作者：
Jiang, Guibin
中科院分区：
文献类型：
--
作者：
Han, Xu;Zhang, Feng;Jiang, Guibin
据报道，有机氯农药（OCPs）与2型糖尿病的风险升高有关，尽管没有研究关注中国人群中的这种关联。本病例对照研究旨在探讨华东地区人群中OCP与2型糖尿病的关系及其可能机制。来自中国东部山东省的被诊断为2型糖尿病的参与者和非糖尿病参与者被纳入这项病例对照研究。在75%以上的血清样本中检测到六种有机氯农药（乙型六氯环己烷、反式氯丁酰草胺、反式九氯草胺、p，p '-DDE、p，p'-DDT和灭蚁灵/酮）。采用Logistic回归分析和多元线性回归分析OCP暴露与预后的关系。在调整了年龄、性别和体重指数等潜在混杂因素后，所有6种OCP均以线性剂量反应方式与2型糖尿病呈正相关。在没有糖尿病的参与者中，乙型六氯环己烷和p，p '-DDE的血清浓度与较高的空腹血糖水平有关，尽管没有有机氯农药与血红蛋白A1 c有显著的关联。此外，在非糖尿病患者中，某些OCP与甘油三酯、总胆固醇和低密度脂蛋白胆固醇呈显著正相关，与高密度脂蛋白胆固醇呈负相关，表明OCP暴露可能会破坏脂质代谢。本研究的结果表明，OCP可能是本研究人群中的一个致糖尿病因素。据我们所知，这是第一个研究OCP暴露与中国人群2型糖尿病之间的关系。
Organochlorine pesticides (OCPs) have been reported to be associated with an elevated risk of type 2 diabetes, although no study has focused on such associations in Chinese populations. In this case-control study, we aimed to explore the associations between OCPs and type 2 diabetes and their potential mechanisms in a population from East China. Participants diagnosed with type 2 diabetes and nondiabetic participants from Shandong Province, East China, were enrolled in this case-control study. Six OCPs (beta-HCH, trans-chlordane, trans-nonachlor, p,p'-DDE, p,p'-DDT and mirex/kepone) were detected in more than 75% of serum samples. Logistic regression analysis and multiple linear regression analysis were used to assess the associations between OCP exposure and the outcomes. After adjusting for potential confounding factors such as age, sex and body mass index, all six OCPs showed positive associations with type 2 diabetes in a linear dose-response manner. Serum concentrations of beta-HCH and p,p'-DDE were associated with higher levels of fasting plasma glucose in participants without diabetes, although no OCPs showed significant associations with hemoglobin A1c. In addition, certain OCPs showed significantly positive associations with triglycerides, total cholesterol, and low-density lipoprotein cholesterol and negative relationships with high-density lipoprotein cholesterol in nondiabetics, indicating that OCP exposure may disrupt lipid metabolism. Findings in the current study indicated that OCPs may be a diabetogenic factor in the population of this study. To our knowledge, this is the first study to investigate the associations between OCP exposure and type 2 diabetes in a Chinese population.