STATUS OF PRIMAQUINE .3. TOXICITY OF PRIMAQUINE IN CAUCASIANS
STATUS OF PRIMAQUINE .3. TOXICITY OF PRIMAQUINE IN CAUCASIANS
复制标题
DOI：
10.1001/jama.1952.72930340022010b
复制
发表时间：
1952-01-01
影响因子：
120.7
通讯作者：
ALVING, AS
中科院分区：
文献类型：
--
作者：
CLAYMAN, CB;ARNOLD, J;ALVING, AS
Primaquine was administered to 699 adult white subjects in a dosage range of 10 to 240 mg./day. On the basis of symptoms and laboratroy findings it is concluded that, at dosages of 15 mg., primaquine may be safely administered daily for 2 wks. without special medical supervision. Adult white patients may be followed on an ambulatory basis when receiving doses as high as 30 mg./day. If it is ever used at higher dosages or administered to patients having diseases known to affect the bone marrow or blood, primaquine should be given only during hospital supervision. Weekly and semiweekly admn. of primaquine for as long as 52 wks. in doses of 30 mg. to 50 subjects did not reveal dangerous toxicity when combined with 0.3 g. of chloroquine. All dosages have been expressed in terms of base weight.
