Naratriptan Prophylactic Treatment in Cluster Headache
Naratriptan Prophylactic Treatment in Cluster Headache
复制标题
那拉曲坦预防性治疗丛集性头痛
DOI：
10.1046/j.1468-2982.2001.00173.x
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发表时间：
2001
期刊：
影响因子：
4.9
通讯作者：
P. Koehler
中科院分区：
文献类型：
--
作者：
Pje Eekers;P. Koehler
在过去的15年里，丛集性头痛的治疗有所改善。氧气吸入(1，2)和舒马曲坦皮下注射(3，4)对急性治疗最有效。维拉帕米(5)、泼尼松(6，7)和锂(7，8)是首选的预防药物。尽管有这些治疗选择，相当多的患者，特别是那些患有慢性丛集性头痛的患者，对当前的预防药物是屈光的。对于这些患者，已经提出了各种手术方法(9例)，包括蝶腭神经节阻断(10例)，但大多数仍然没有得到缓解。那曲普坦是一种新的选择性5-羟色胺激动剂，用于偏头痛的急性治疗(11)。它还被用于预防慢性日常头痛(12例)和经期偏头痛(13例)。在这份报告中，我们描述了那曲普坦在慢性丛集性头痛患者中的预防性使用。
The treatment of cluster headache has improved over the last 15 years. Oxygen inhalation (1, 2), and sumatriptan subcutaneous injection (3, 4) are most effective for the acute treatment. Verapamil (5), prednison (6, 7) and lithium (7, 8) are the prophylactic drugs of choice. Despite these treatment options, a considerable number of patients, in particular those with chronic cluster headache, are refractive to current prophylactic agents. Various surgical procedures have been proposed for these patients (9), including sphenopalatine ganglion blockade (10), but still the majority do not® nd relief. Naratriptan is a new selective 5-HT agonist, developed for the acute treatment of migraine (11). It has also been used for the prevention of chronic daily headache (12) and menstrual migraine (13). In this report, we describe the prophylactic use of naratriptan in a chronic cluster headache patient.