Genome research elucidating environmental adaptation: Dark-fly project as a case study
Genome research elucidating environmental adaptation: Dark-fly project as a case study
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基因组研究阐明环境适应：以暗蝇项目为例
DOI：
10.1016/j.gde.2017.03.004
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发表时间：
2017
影响因子：
4
通讯作者：
Naoyuki Fuse
中科院分区：
文献类型：
--
作者：
Naoyuki Fuse
重点介绍基因组科学已经解决了潜在的环境适应机制。黑蝇是一种独特的研究环境适应的生物。黑蝇基因组在黑暗条件下重新选择。我们确定了参与黑蝇暗适应的候选基因。生物具有适应不同环境的能力，环境适应是进化的重要驱动力。基因组科学的最新进展已经解决了环境适应的遗传机制。全基因组测序已经确定了在特定环境下选择的适应性基因。基因组编辑技术使我们能够直接测试基因在环境适应中的作用。基因组科学还揭示了一种独特的生物体，暗蝇，它一直在黑暗中饲养。我们测定了黑蝇的全基因组序列，并对黑蝇基因组进行了环境选择，以确定与暗适应相关的基因。在这里，我将概述基因组科学的当前进展，并总结我们的研究使用暗蝇，作为环境适应的案例研究。
HighlightsGenome science has addressed the mechanisms underlying environmental adaptation.Dark-fly is a unique organism for studying environmental adaptation.The Dark-fly genome was reselected in dark conditions.We identified candidate genes involved in dark-adaptation of Dark-fly.Organisms have the capacity to adapt to diverse environments, and environmental adaptation is a substantial driving force of evolution. Recent progress of genome science has addressed the genetic mechanisms underlying environmental adaptation. Whole genome sequencing has identified adaptive genes selected under particular environments. Genome editing technology enables us to directly test the role (s) of a gene in environmental adaptation. Genome science has also shed light on a unique organism, Dark-fly, which has been reared long-term in the dark. We determined the whole genome sequence of Dark-fly and reenacted environmental selections of the Dark-fly genome to identify the genes related to dark-adaptation. Here I will give an overview of current progress in genome science and summarize our study using Dark-fly, as a case study for environmental adaptation.