Inactivation of the melanin concentrating hormone system impairs maternal behavior
Inactivation of the melanin concentrating hormone system impairs maternal behavior
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DOI：
10.1016/j.euroneuro.2016.08.014
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发表时间：
2016-11-01
影响因子：
5.6
通讯作者：
Civelli, Olivier
中科院分区：
文献类型：
--
作者：
Alachkar, Amal;Alhassen, Lamees;Civelli, Olivier
为了使母亲为怀孕和哺乳的需要做好准备，母亲的大脑经历了一系列的适应。母亲的行为受复杂的神经元相互作用的调节。在这里，我们表明黑色素浓缩激素(MCH)系统是母性行为的重要调节因素。首先，我们报告了黑色素浓缩激素受体1基因敲除(MCHR1KO)小鼠表现出母性行为的中断。产后早期，雌性MCHR1KO表现出巢不好、取回幼崽的缺陷和母亲的攻击性。此外，消融MCH受体会导致产奶量和催乳素mRNA水平下降。然后，我们证明这些结果与用MCHR1特异性拮抗剂GW803430处理野生型小鼠(WT)的结果是一致的。此外，在取回幼鼠后，MCHR1 KO小鼠在腹侧被盖区和伏隔核中的Fos表达水平低于WT小鼠。然而，随着哺乳期的进展，MCHR1 KO小鼠改善了对其幼崽的母爱。这表现为产后第二天以上幼崽存活率的提高和恢复时间的缩短。在此背景下，MCH可能在整合来自多个来源的信息，以及连接大脑奖励、内环境平衡和调节系统方面发挥作用。(C)2016年爱思唯尔和ECNP。版权所有。
In order to prepare the mother for the demands of pregnancy and lactation, the maternal brain is subjected to a number of adaptations. Maternal behaviors are regulated by complex neuronal interactions. Here, we show that the melanin concentrating hormone (MCH) system is an important regulator of maternal behaviors.First, we report that melanin concentrating hormone receptor 1 knockout (MCHR1 KO) mice display a disruption of maternal behavior. Early postpartum MCHR1 KO females exhibit poor nesting, deficits in pup retrieval and maternal aggression. In addition, ablation of MCH receptors results in decreased milk production and prolactin mRNA levels. Then we show that these results are in line with those obtained in wild type mice (WT) treated with the specific MCHR1 antagonist GW803430. Furthermore, following pups retrieval, MCHR1 KO mice display a lower level of Fos expression than WT mice in the ventral tegmental area, and nucleus accumbens. With the progression of the lactation period, however, the MCHR1 KO mice improve maternal care towards their pups. This is manifested by an increase in the pups' survival rate and the decrease in pups' retrieval time beyond the second day after parturition.In conclusion, we show that the MCH system plays a significant role in the initiation of maternal behavior. In this context, MCH may play a role in integrating information from multiple sources, and connecting brain reward, homeostatic and regulatory systems. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.